Genotoxicity testing of tetramethrin in the Drosophila SMART assay

Saygın, Ö.; Golal, Ezgi; Yalçın, Burçin; Güneş, Merve; Kaya, Bülent

doi:10.1016/j.toxlet.2016.06.1695

Cited by 1 publication

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“…Tetramethrin (Tet) is one of the most effective synthetic pyrethroids (SPs) in the control of mosquitoes and flies, with rapid knockdown effects on such sanitary pests [ 14 ]. Tet has two chiral centers resulting in four stereoisomers, with its primary active components being the two enantiomers of trans -Tet.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (Danio rerio)

Feng,

Xu,

Huang

et al. 2024

Toxics

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Chiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric toxicity studies at different developmental stages of organisms can help deepen the understanding of the ecological effects of chiral pesticides. This study focused on trans-tetramethrin (Tet) and investigated the enantioselectivity in bioconcentration, developmental toxicity, estrogenic effects, and immunotoxicity of Tet’s racemate ((±)-Tet) and its two enantiomers ((+)-Tet and (−)-Tet) in three developmental stages of zebrafish: embryos, yolk sac larvae, and juveniles. The results showed that Tet exhibited different enantioselectivity in lethal, bioconcentration, and teratogenic effects on zebrafish at different developmental stages. The LC50 value was (+)-Tet > (±)-Tet > (−)-Tet, with embryos being the most sensitive, followed by juveniles and yolk sac larvae. The enantioselective bioconcentration was (±)-Tet > (+)-Tet > (−)-Tet, and the bioconcentration effect was greater in embryos than that in yolk sac larvae and juveniles. Developmental toxicity indicated that (+)-Tet and (±)-Tet had higher teratogenic effects on yolk sac larvae than on embryos. Tet exhibited different enantioselective effects on the expression of zebrafish estrogen-related genes and innate immune-related genes at different developmental stages. These results will contribute to a more comprehensive assessment of the aquatic toxicity and environmental risks of chiral pesticides.

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Section: Introductionmentioning

confidence: 99%