Genotoxicological Assessment of Nebuloside-A a Triterpenoid Saponin Compound on Whole Blood DNA

Arslan, İdris; İli, Pınar

doi:10.1080/10942912.2014.971185

Cited by 16 publications

(7 citation statements)

References 18 publications

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“…Our findings as well as literature data allow us to suggest that constituents such as linalool, terpinen-4-ol, and 1,8-cineole, alongside oxygenated sesquiterpenes, might contribute to antimicrobial activity agree with earlier reports. [23,42,[43][44] Although these compounds are not abundant in essential oil, their activity is important. It is necessary to signal that other components can contribute to improve this activity.…”

Section: Disc Diffusion Methodsmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Moghaddam

Mehdizadeh

Najafgholi

et al. 2018

International Journal of Food Properties

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The aim of this study was to determine the chemical composition and the in vitro antimicrobial effects of seed essential oil of Ferulago angulata. The oil analyses by GC and GC/MS resulted in the identification of 39 compounds representing 91.07% of the oil. The major constituents were (Z)-β-ocimene (19.93%), α-pinene (15.50%), p-cymene (7.67%), sabinene (7.49%), β-phellandrene (5.5%), and α-phellandrene (4.95%). The oil was also screened for its antimicrobial properties against six bacteria (Erwinia amylovora, Xanthomonas oryzae, Pseudomonas syringae, Pectobacterium carotovorum, Ralstonia solanacearum, Bacillus thuringiensis) and six fungi (Alternaria alternata, Culvularia fallax, Macrophomina phaseolina, Fusarium oxysporum, Cytospora sacchari, Colletotrichum tricbellum). According to the results of antibacterial activity, B. thuringiensis (with 8 µL mL −1 minimal inhibitory concentration (MIC) and 15 µL mL −1 minimum bactericidal concentration (MBC)) was the most sensitive bacterium; P. carotovorum and R. solanacearum (with 20 µL mL −1 MIC and 30< MBC) were the most resistant bacteria. Additionally, a broad differentiation against all of the tested fungi showed that the most susceptible and resistant fungi after 6 days at the highest concentration (800 µL L −1 ) were F. oxysporum (100.0 ± 0.00%) and C. tricbellum (52.50 ± 1.67%) of growth inhibition, respectively. ARTICLE HISTORY

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Section: Disc Diffusion Methodsmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Moghaddam

Mehdizadeh

Najafgholi

et al. 2018

International Journal of Food Properties

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“…exhibited genotoxic properties in a micronucleus assay [26]. DNA-damaging activity was also shown for nebuloside A isolated from Gypsophila arrostii [27]. Our data indicate that the CIL-1/2 fraction from L. ciliata (concentration up to 0.5 μg/mL) may be used as an adjuvant in MTX-based therapy of prostate cancer, and it does not increase the risk of genetic perturbations in normal cells.…”

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confidence: 53%

Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells

et al. 2016

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Triterpene saponins are secondary metabolites typical for higher plants. They possess a wide range of pharmaceutical and biological activities. These include anti-inflammatory, vasoprotective, expectorant, and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs has opened new perspectives for their application in combined cancer chemotherapy. In this study, the biological activity of the saponin fraction isolated from (denoted as CIL-1/2) was evaluated to assess its chemosensitizing activity in prostate cancer cell lines (DU-145, PC-3). No cytotoxic or cytostatic effect of the CIL-1/2 fraction administered at the concentration of 0.5 µg/mL was observed. In contrast, cocktails of CIL-1/2 and mitoxantrone (a drug commonly used in prostate cancer therapy) exerted synergistic cytostatic and proapoptotic effects. Furthermore, the synergy of proapoptotic activities of the analyzed cocktails is accompanied by their synergistic effects on prostate cancer cell movement and invasiveness. The significantly weaker impact of this cocktail on normal prostate cells additionally adds to the significance of our data and confirms that the CIL-1/2 fraction might be considered a potent adjuvant for prostate cancer chemotherapy.

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“…We have previously reported that purification and structural elucidation of natural triterpenoidal saponins and their forceful activities, such as genotoxicological effects, enhance toxicity of type-I ribosome inactivating proteins (Arslan, 2014a(Arslan, , b, 2017Arslan et al 2012Arslan et al , 2013Arslan and Ili 2015).…”

Section: Occurrence Isolation and Identificationmentioning

confidence: 99%

N-triterpene Saponins in Cancer Therapy: a Review of Mode of Action

Arslan

Cenzano

2020

Rev. Bras. Farmacogn.

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Genotoxicological Assessment of Nebuloside-A a Triterpenoid Saponin Compound on Whole Blood DNA

Cited by 16 publications

References 18 publications

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells

N-triterpene Saponins in Cancer Therapy: a Review of Mode of Action

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