Genotype 1 of hepatitis C virus increases the risk of major depression: a 12-week prospective study

Cunha, Elza Cristina Miranda da; Behrensdorf, M.F.; Bavaresco, V.; Zambrano, D.; Bellini, J.; Kaster, Manuella P.; Spessato, Bárbara Coiro; Ghisleni, Gabriele

doi:10.1016/j.genhosppsych.2015.03.016

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…Evidence also exists for association of depression with impaired cellular immunity [31], highlighting the complexity of proposed mechanisms. Indeed, a recent study of a smaller cohort of 50 patients reported HCV genotype 1 to have greater association with IFNα-induced depression, defined by the Mini International Neuropsychiatric Interview (MINI) [32]. This genotype association clearly warrants further exploration.…”

Section: Baseline Weekmentioning

confidence: 97%

Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort

Whale

Fialho

Rolt

et al. 2015

Journal of Psychosomatic Research

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Section: Baseline Weekmentioning

confidence: 97%

Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort

Whale

Fialho

Rolt

et al. 2015

Journal of Psychosomatic Research

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“…At present, the prevalence of depression is high, with 37.9% of the total population with depressive symptoms and 4.1% diagnosed of depression . Prospective evidence shows that there is an association of some other types of hepatitis, such as hepatitis C, with major depression, as hepatitis C genotype 1 was found to be related to a higher risk for psychiatric symptoms during the follow‐up . In hepatitis B patients, one Chinese study with a relatively small sample size shows that 57.6% of the 132 HBV patients were detected of various symptoms of depression, which is significantly larger than the general prevalence of depressive symptoms (37.9%) among Chinese adults .…”

Section: Introductionmentioning

confidence: 98%

The association between hepatitis B self‐awareness and depression: Exploring the modifying effects of socio‐economic factors

Liu

Tang

Long

et al. 2016

Journal of Viral Hepatitis

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China has a high prevalence of HBV. Despite previous studies, uncertainty remains about the association of HBV with depression. This study explores the strength of the association and the modifying effects of participants' self-awareness of the disease and their socio-economic status. Data from the baseline of a Chinese cohort study of approximately 500 000 adults were analysed. Depression was assessed using the Composite International Diagnostic Inventory. Blood spot tests were conducted to detect hepatitis B surface antigen. Logistic regression was used to assess the association between depression and HBV adjusting for demographic, socio-economic and lifestyle factors of major depression. To understand the effect modifications of disease self-awareness and socio-economic factors, a series of stratified analyses were undertaken. The overall prevalence of HBV is 3.2%, with 2.8% screen-detected and 0.3% self-reported cases. There was an 84% increased odds of depression among self-reported HBV patients (OR=1.84, 95% CI: 1.16-2.90), but no association was found in the screen-detected group (OR=0.98, 95% CI: 0.79-1.23). Male (OR=2.28, 95% CI: 1.30-3.98), younger age (OR=3.57, 95% CI: 1.82-7.00), rural resident (OR=2.31, 95% CI: 1.36-3.94), lower household income (OR=2.38, 95% CI: 1.34-4.25) and agricultural worker (OR=2.92, 95% CI: 1.63-5.77) were found having greater odds of depression in the HBV self-aware group, compared to those without HBV. A strong association between hepatitis B self-awareness and depression was found. Lower socio-economic status could modify the association between hepatitis B status and depression. Further studies are needed to understand the underlying psychosocial mechanisms of the association.

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“…The evidence suggests that neuropsychiatric side effects of IFN- therapy occur during the time course of treatment, with a tendency to emerge at the beginning of treatment, between week 4 and week 12 (Cunha et al, 2015;Leutscher et al, 2010;Martín-Santos et al, 2007). The HCV monoinfected group reported significantly higher scores on depression than the co-infected group only at…”

Section: Discussionmentioning

confidence: 99%

Co-infection with HIV associated with reduced vulnerability to symptoms of depression during antiviral treatment for hepatitis C

Fialho

Pereira

Harrison

et al. 2017

Psychiatry Research

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In this prospective study, we examined new-onset major depressive disorder (MDD) and the differential expression of depressive symptoms in a sample of 132 HCV mono-infected and 40 HIV/HCV co-infected patients initiating pegylated interferon-based treatment, including protease inhibitor therapy. The semi-structured clinical interview (SCID-I) was used to assess MDD. Severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Of the total sample, 60 patients (34.9%) developed SCID-I defined MDD during antiviral treatment. The proportion of HCV mono- and HIV/HCV patients developing MDD during treatment was not significantly different (37.9% vs. 25%; p=0.185). In both groups, there was a significant increase in HAMD total score from baseline to week 4, and a significant decrease between week 24 and 6 months post-treatment cessation. The greatest increase was observed in the symptoms of the neurovegetative syndrome. HCV mono-infected patients reported higher scores than co-infected patients, particularly impaired activity and somatic symptoms, but the differences were only significant at week 12. The finding that co-infected patients appear less vulnerable to the development of depressive symptoms during HCV treatment than HCV mono-infected patients warrants further exploration, including a thorough analysis of the biological and psychosocial factors associated with this emergence.

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Genotype 1 of hepatitis C virus increases the risk of major depression: a 12-week prospective study

Cited by 8 publications

References 31 publications

Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort

Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort

The association between hepatitis B self‐awareness and depression: Exploring the modifying effects of socio‐economic factors

Co-infection with HIV associated with reduced vulnerability to symptoms of depression during antiviral treatment for hepatitis C

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