Genotype analysis based on intergenic spacer 1 sequences of<i>Trichosporon asahii</i>collected in Taiwan

Yang, Yun-Liang; Liu, Yi Wen; Chen, Huiting; Tsai, Moan-Shane; Chu, Wen-Li; Lo, Hsiu‐Jung

doi:10.3109/13693786.2013.800240

Cited by 19 publications

(19 citation statements)

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“…Details from 19 studies having tested at least 10 Trichosporon clinical isolates for a given species with a microdilution method are presented in Tables 3 – 8 (Arikan and Hasçelik, 2002 ; Paphitou et al, 2002 ; Ramos et al, 2004 ; Metin et al, 2005 ; Rodriguez-Tudela et al, 2005 ; de Oliveira Silva et al, 2008 ; Chagas-Neto et al, 2009 ; Taj-Aldeen et al, 2009 ; Thompson et al, 2009 ; Lemes et al, 2010 ; Mekha et al, 2010 ; Guo et al, 2011 ; Sun et al, 2012 ; Tsai et al, 2012 ; Hazirolan et al, 2013 ; Yang et al, 2013 ; Arabatzis et al, 2014 ; Taverna et al, 2014 ; Montoya et al, 2015 ). Up to now, there is no recommendation from the two main consortia (EUCAST and CLSI) regarding the AST of Trichosporon .…”

Section: Resultsmentioning

confidence: 99%

Invasive Trichosporon Infection: a Systematic Review on a Re-emerging Fungal Pathogen

2016

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Objectives: This review aimed to better depict the clinical features and address the issue of therapeutic management of Trichosporon deep-seated infections.Methods: We comprehensively reviewed the cases of invasive Trichosporon infection reported in the literature from 1994 (date of taxonomic modification) to 2015. Data from antifungal susceptibility testing (AST) studies were also analyzed.Results: Two hundred and three cases were retained and split into four groups: homeopathy (n = 79), other immunodeficiency conditions (n = 41), miscellaneous (n = 58) and newborns (n = 25). Trichosporon asahii was the main causative species (46.7%) and may exhibit cross-resistance to different antifungal classes. The unfavorable outcome rate was at 44.3%. By multivariate analysis, breakthrough infection (OR 2.45) was associated with unfavorable outcome, whilst the use of an azole-based therapy improved the prognosis (OR 0.16). Voriconazole-based treatment was associated with favorable outcome in hematological patients (73.6 vs. 41.8%; p = 0.016). Compiled data from AST demonstrated that (i) T. asahii exhibits the highest MICs to amphotericin B and (ii) voriconazole has the best in vitro efficacy against clinical isolates of Trichosporon spp.Conclusions: Trichosporon infection is not only restricted to hematological patients. Analysis of compiled data from AST and clinical outcome support the use of voriconazole as first line therapy.

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Section: Resultsmentioning

confidence: 99%

Invasive Trichosporon Infection: a Systematic Review on a Re-emerging Fungal Pathogen

2016

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“…Interestingly, our results found that genotype 3 strains exhibited higher AMB MICs (Ն2 g/ml) than did genotype 1 strains (P ϭ 0.009). Sun et al pointed out that genotype 3 strains were more capable of hemolysis and biofilm formation (12), and Yang et al found that genotype 4 isolates were more resistant to antifungal agents (28). However, more work is needed on the possible association between genotypes, virulence, and drug resistance in the pathogenesis of human invasive infections.…”

Section: Discussionmentioning

confidence: 99%

Invasive Infections Due to Trichosporon : Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China

Guo

Hsueh

et al. 2019

J Clin Microbiol

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A total of 133 clinical Trichosporon isolates were collected in the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program in 2009 to 2016. Accurate identification was performed by sequencing of the intergenic spacer 1 (IGS1) region. Among these isolates, Trichosporon asahii (108 isolates [81.2%]) was the leading species, followed by Trichosporon dermatis (7 isolates [5.3%]), Trichosporon asteroides (5 isolates [3.8%]), Trichosporon inkin (5 isolates [3.8%]), Trichosporon dohaense (3 isolates [2.3%]), and 1 isolate (0.7%) each of Trichosporon faecale, Trichosporon jirovecii, Trichosporon mucoides, Trichosporon coremiiforme, and Trichosporon montevideense. Both the Vitek mass spectrometry (MS) (bioMérieux, Marcy l'Etoile, France) and Bruker Biotyper MS (Bruker Daltonics GmbH, Germany) platforms gave high levels (Ͼ97.5%) of correct identification when the species were present in the database. The geometric mean (GM) of amphotericin B MICs for T. asahii was 2-fold higher than that for non-asahii Trichosporon. High fluconazole MICs (Ն8 g/ml) were observed for 25% of T. asahii isolates (27/108 isolates) and 16% of non-asahii Trichosporon (4/25 isolates) isolates. Itraconazole MICs were Յ0.5 g/ml for 89.5% of the isolates. Voriconazole was the most potent antifungal agent in vitro, with a GM of 0.09 g/ml. Genotyping of the isolates using IGS1 sequence alignment revealed that genotype 1 was most common (41.7%), followed by genotype 4 (31.5%), genotype 3 (23.1%), genotype 5 (0.9%), genotype 6 (0.9%), and genotype 7 (1.8%). Our data on species distribution, genotypes, and antifungal susceptibilities may contribute to a better understanding of the epidemiology of invasive Trichosporon infections throughout China.

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“…However, from 2010 onward the first sporadic cases of Trichosporon spp . resistant to voriconazole were reported [ 9 , 10 ], and a recent study from Greece reported that 38 % of Trichosporon isolates had a MIC ≥ 2 mg/L for voriconazole [ 11 ]. Most of these strains were susceptible to at least one other triazole, and treatment failures were not described in this study.…”

Section: Discussionmentioning

confidence: 99%

Emerging pan-resistance in Trichosporon species: a case report

et al. 2016

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BackgroundTrichosporon species are ubiquitously spread and known to be part of the normal human flora of the skin and gastrointestinal tract. Trichosporon spp. normally cause superficial infections. However, in the past decade Trichosporon spp. are emerging as opportunistic agents of invasive fungal infections, particularly in severely immunocompromised patients. Clinical isolates are usually sensitive to triazoles, but strains resistant to multiple triazoles have been reported.Case presentationWe report a high-level pan-azole resistant Trichosporon dermatis isolate causing an invasive cholangitis in a patient after liver re-transplantation. This infection occurred despite of fluconazole and low dose amphotericin B prophylaxis, and treatment with combined liposomal amphotericin B and voriconazole failed.ConclusionThis case and recent reports in literature show that not only bacteria are evolving towards pan-resistance, but also pathogenic yeasts. Prudent use of antifungals is important to withstand emerging antifungal resistance.

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Genotype analysis based on intergenic spacer 1 sequences ofTrichosporon asahiicollected in Taiwan

Cited by 19 publications

References 29 publications

Invasive Trichosporon Infection: a Systematic Review on a Re-emerging Fungal Pathogen

Invasive Trichosporon Infection: a Systematic Review on a Re-emerging Fungal Pathogen

Invasive Infections Due to Trichosporon : Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China

Emerging pan-resistance in Trichosporon species: a case report

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