Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Abstract

Abstract.Vietnam is one of the countries with a high rate of hepatitis B virus (HBV) infection, but there are only a few reports about relation of HBV genotypes and mutations to clinical course in Northern Vietnam. The characteristics of HBV and its relationship to clinical outcome in patients from Northern Vietnam were analyzed. Serum samples were collected from 183 HBV-infected Vietnamese patients. They were clinically categorized into 4 groups: hepatocellular carcinoma (HCC), liver cirrhosis (LC), chronic hepatitis (CH), and asymptomatic carriers (ASC). HBV serology, ·-fetoprotein, HBV genotypes, HBV-DNA level and mutations in the core promoter and pre-core regions of HBV-DNA were examined. The majority of sera contained HBV genotype B (67.8%) and C (27.9%). The median age was matched between genotype B and C (38.2 vs. 42.9 years). The rates of HBeAg seroconversion and G1896A for genotype B were significantly higher than those for genotype C (P<0.05). Genotype C had a higher HBV-DNA level than genotype B. C1858 was frequent, especially in genotype C (62.7%). The most prevalent genotype in ASC and CH was genotype B. The presence of the mutation A1762T/G1764A correlated with disease progression. The triple mutation T1753C/A1762T/ G1764A was quite common and was more prevalent in LC and HCC than in CH and ASC. In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases.

Prevalence of Hepatitis B Virus and Hepatitis C Virus Infections among Beauticians in Quy Nhon City, Binh Dinh Province, Vietnam

“…31 Our result was similar to previous studies conducted in Vietnam that indicated that HBV genotype B was the most prevalent (63.0%-72.6%) followed by genotype C (18.0%-28.0%). [32][33][34][35] Like other studies, 5,6,23,24,28,36 our results also showed no statistically significant association between possible occupational risk factors for HBV infection among beauticians. However, some studies have suggested that beauticians are a high-risk group for HBV and HCV infections based on the statistically significant difference in prevalence among case and control groups, 24,36,37 or by comparing HBV infected cases with HAV infected cases as a control group.…”

Prevalence of Hepatitis B Virus Subgenotypes and Basal Core Promoter, Precore Variants in Patients with Acute Hepatitis B in Central Vietnam

“…Each subgenotype has a unique geographic distribution and virological characteristics. Vietnam is one of the most endemic areas of HBV infection, and the prevalence of HBV subgenotypes in patients with chronic hepatitis in Vietnam has been reported [5][6][7][8] . HBV subgenotypes C1 and B4 are frequently found in Vietnam.…”

The rtA181 Mutation Produces Similar Clinical and Cellular Characteristics in Patients infected with Hepatitis B Virus Genotypes B and C

“…22 In China, genotypes B and C are the two most commonly found genotypes, that contributing 90% of the population of chronic hepatitis B patients. The clinical importance of genotype related differences in CHB patients remains incompletely understood.…”