Genotype distribution of Candida albicans strains associated with different conditions of vulvovaginal candidiasis, as revealed by microsatellite typing

Fan, Shang Rong; Bai, Feng‐Yan; Liao, Qinping; Liu, Z H; Li, J; Liu, X P

doi:10.1136/sti.2007.025700

Cited by 36 publications

(34 citation statements)

References 32 publications

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“…Different genotyping methods may result in different groupings of isolates. For example, inconsistent with our observations based on CAI polymorphism (8,11), genotyping of vaginal C. albicans isolates by using randomly amplified polymorphic DNA (RAPD) analysis failed to show any relationship between genotypes and VVC patient groups (3,12). Another possible reason is that the genotype distribution patterns of VVC causing C. albicans isolates in Chinese and European women may be different.…”

Section: Discussioncontrasting

confidence: 52%

“…These two dominant genotypes were rarely found among isolates from extragenital sites (11). In addition, the distribution of the dominant genotypes correlated positively with the severity of VVC (8,11). These results suggested that C. albicans isolates with genotypes CAI 30-45 and CAI 32-46 might be more virulent and/or more resistant to the commonly used azole drugs than those with other genotypes as causative agents of vaginal infection.…”

mentioning

confidence: 63%

“…Recently, we compared the genotype distribution patterns among independent C. albicans isolates associated with VVC in Chinese women and those from various extragenital sites by using the polymorphic microsatellite locus CAI (8,11). The results showed that the CAI genotypes of C. albicans isolates from extragenital sites were highly diversified.…”

mentioning

confidence: 99%

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Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Wan

et al. 2010

Antimicrob Agents Chemother

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The relationship between susceptibilities to fluconazole and itraconazole and microsatellite CAI genotypes were examined from a total of 154 Candida albicans isolates (97 isolates causing vulvovaginitis in Chinese women and 6 vaginal isolates and 51 oral cavity isolates from asymptomatic carriers). The two dominant genotypes, CAI 30-45 (45 isolates) and CAI 32-46 (33 isolates), associated with vulvovaginitis showed significantly different azole susceptibility patterns with strong statistical support. CAI 32-46 isolates were usually less susceptible to both fluconazole and itraconazole than CAI 30-45 isolates and than the oral isolates with other diversified CAI genotypes. Remarkably different mutation patterns in the azole target gene ERG11 were correspondingly observed among C. albicans isolates representing different genotypes and sources. Isolates with the same or similar CAI genotypes usually possessed identical or phylogenetically closely related ERG11 sequences. Loss of heterozygosity in ERG11 was observed in all the CAI 32-46 isolates but not in the CAI 30-45 isolates and most of the oral isolates sequenced. Compared with the ERG11 sequence of strain SC5314 (X13296), two homozygous missense mutations (G487T and T916C) leading to two amino acid changes (A114S and Y257H) in Erg11p were found in CAI 32-46 isolates. The correlation between azole susceptibility and C. albicans genotype may be of potential therapeutic significance.

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Section: Discussioncontrasting

confidence: 52%

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confidence: 63%

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Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Wan

et al. 2010

Antimicrob Agents Chemother

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“…RAPD analysis has also been used to resolve populations in various species, such as S. cerevisiae, S. bayanus var. uvarum, C. albicans and C. glabrata [65][66][67][68][69][70][71][72]. One concern in using pattern-based identification techniques is reproducibility between laboratories, because small differences in PCR conditions may impact the species-specific patterns that serve as reference.…”

Section: Candida Dubliniensismentioning

confidence: 99%

Recognition of Yeast Species from Gene Sequence Comparisons

Kurtzman¹

2011

TOAINFOJ

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This review discusses recognition of yeast species from gene sequence comparisons, which have been responsible for doubling the number of known yeasts over the past decade. The resolution provided by various single gene sequences is examined for both ascomycetous and basidiomycetous species, and the greater resolution of species provided by multigene analyses is discussed. Various methods are presented for rapid species identification using gene sequences.

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“…Different primer pairs and also different combinations of primer pairs for the subtyping of C. albicans were reported elsewhere, see e.g. the works of Sampaio et al (2005) or Fan et al (2007).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite Typing of Catheter-Associated Candida albicans Strains

Paulitsch-Fuchs¹,

Heiling²,

Willinger³

et al. 2012

Epidemiology Insights

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Genotype distribution of Candida albicans strains associated with different conditions of vulvovaginal candidiasis, as revealed by microsatellite typing

Abstract: The frequency of C albicans strains with the dominant genotypes (A to D) from patients with severe VVC was significantly higher than that from patients with mild-to-moderate VVC, implying that the CAI genotype distribution of C albicans strains correlates with the severity of VVC.

Cited by 36 publications

References 32 publications

Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Recognition of Yeast Species from Gene Sequence Comparisons

Microsatellite Typing of Catheter-Associated Candida albicans Strains

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