Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective

Riccetto, Adriana Gut Lopes; Silva, Luciana Helena Antoniassi da; Spilki, Fernando Rosado; Morcillo, André Moreno; Arns, Clarice Weis; Baracat, Emílio Carlos Elias

doi:10.1590/s1413-86702009000100008

Cited by 19 publications

(24 citation statements)

References 36 publications

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“…Compared to other tested viruses, RSV was significantly more common in this age group [5]. A predominance of RSV and human metapneumovirus (hMPV) was observed in Brazil and in other countries [9]. While the role of respiratory viruses including hMPV and RSV is well established in causing self-limiting upper respiratory tract infections or mild pneumonia, their contribution to causing severe and radiologically proven pneumonia in developing countries is less clear [10].…”

Section: Introductionmentioning

confidence: 89%

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Othman

Elhamed

Hassan

et al. 2016

J Infect Dev Ctries

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Introduction: Viruses are the most important causative agents of acute lower respiratory tract infections (ALRTIs), ranked as the second leading cause of death and the primary cause of hospitalization in children. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are among the commonest viral causes of severe ALRTI. In this study, we aimed to study the burden of both RSV and hMPV in causing severe ALRTI in children younger than two years of age admitted to the pediatric intensive care unit (PICU). Methodology: Nasopharyngeal swabs were collected from children admitted to the PICU with a diagnosis of community-acquired ALRTI who were two years of age or younger. Real-time polymerase chain reaction (RT-PCR) was used to test for RSV and hMPV. Results: A total of 127 swabs were screened for RSV and hMPV, of which 49.6% were negative for RSV and hMPV, 46.4% were positive for RSV, and 3.9% were positive for hMPV. With respect to RSV, the mean age of cases (4.01 ± 5.05) and the monthly distribution (mainly January) were the most important risk factors. There were no statistically significant differences between the RSV group and control group regarding duration of hospital stay, mechanical ventilation need or duration, and underlying chronic conditions. Conclusions: RSV is important viral cause of severe ALRTIs in children younger than two years of age during this study period; hMPV played a minor role.

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Section: Introductionmentioning

confidence: 89%

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Othman

Elhamed

Hassan

et al. 2016

J Infect Dev Ctries

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“…Several G protein genotypes within the two subtypes have been identified, including GB1 to GB4 (24). SAA1, SAB1, SAB2, and SAB3 were identified in South Africa (39) and, subsequently, in various other geographic locations (26,30). Venter et al (38) also showed that identical RSV genotypes were identified in different regions in South Africa during one season.…”

Section: Respiratory Syncytial Virus (Rsv) a Member Of The Genusmentioning

confidence: 99%

Replacement of Previously Circulating Respiratory Syncytial Virus Subtype B Strains with the BA Genotype in South Africa

Niekerk

Venter

2011

J Virol

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Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in infants, the immunocompromised, and the elderly in both developed and developing countries. Reinfections are common, and G protein variability is one mechanism to overcome herd immunity. This is illustrated by the appearance of the BA genotype with a 60-nucleotide duplication dominating the subtype B genotypes in epidemics worldwide.

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“…Brazil has already been demonstrated 3,5,8,31,35 . No vaccine or antiviral therapy is currently available for prevention or treatment of HMPV infection.…”

Section: The Burden Of Hmpv Infection Inmentioning

confidence: 99%

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

Mendes

Soares

Martins

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWe evaluated the antiviral activity of the marine alga, Ulva fasciata, collected from Rasa beach and Forno beach, Búzios, Rio de Janeiro, Brazil on the replication of human metapneumovirus (HMPV). The algae extracts were prepared using three different methodologies to compare the activity of different groups of chemical composites obtained through these different methodologies. Four out of the six extracts inhibited nearly 100% of viral replication. The results demonstrated that the majority of the extracts (five out of six) possess virucidal activity and therefore have the ability to interact with the extracellular viral particles and prevent the infection. On the other hand, only two extracts (from Forno beach, obtained by maceration and maceration of the decoction) were able to interact with cell receptors, hindering the viral entry. Finally, only the extract of algae collected at Forno beach, obtained by maceration presented intracellular activity. To our knowledge, this is a pioneer study on antiviral activity of marine algae against HMPV. It is also the first on antiviral activity against HMPV ever done in Brazil. The study also shows the effect of different environment factors and different chemical procedures used to obtain the extract on its biological properties.

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Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective

Cited by 19 publications

References 36 publications

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Replacement of Previously Circulating Respiratory Syncytial Virus Subtype B Strains with the BA Genotype in South Africa

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

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