Genotypes and haplotype combination of
            <i>DCAF7</i>
            gene sequence variants are associated with number of thoracolumbar vertebrae and carcass traits in Dezhou donkey

Wang, Tianqi; Wang, Xinrui; Liu, Ziwen; Shi, Xiaoyuan; Ren, Wei; Huang, Bingjian; Liang, Huili; Wang, Changfa; Chai, Wenqiong

doi:10.1080/09712119.2022.2149538

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…The study found that certain variants in the myostatin gene were associated with body weight and hip height in donkeys, indicating that the myostatin gene may play a role in determining these traits in donkeys. Moreover, many other genes, such as LTBP2 [85], CDKL5 [86], TBX3 [87], LCORL [88], DCAF7 [89], PRKG2 [90], and HOXC8 [91], as well as their polymorphisms, have been reported to be associated with different meat production phenotypic traits in Dezhou donkeys (Table 2). NCAPG-DCAF16 Donkeys with AA and GA genotypes had significantly higher body weight, body height, and rump height compared to those with the GG genotype at 3 months of age (p < 0.05).…”

Section: Genetic Markers Associated With Growth and Meat Production P...mentioning

confidence: 99%

“…Additionally, implementing genomic selection can accelerate genetic gains, but it requires accurate prediction models, validated markers, and high-quality phenotypic data. Finally, future studies should also consider the role of structural variations (SVs), including copy number variations (CNVs), inversions, and translocations [106], as they have received limited research attention but could play a significant role in the adaptive evolution of thoracic and lumbar vertebrae numbers in donkeys [83,85,[89][90][91].…”

Section: Why Have Genetic Markers Associated With Milk and Reproducti...mentioning

confidence: 99%

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Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Huang,

Khan,

Chai

et al. 2023

Animals

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Donkeys (Equus asinus) play a pivotal role as essential livestock in arid and semi-arid regions, serving various purposes such as transportation, agriculture, and milk production. Despite their significance, donkey breeding has often been overlooked in comparison to other livestock species, resulting in limited genetic improvement programs. Preserving donkey genetic resources within each country necessitates the establishment of breed conservation programs, focusing on managing genetic diversity among populations. In recent years, significant strides have been made in sequencing and analyzing complete mitochondrial DNA (mtDNA) molecules in donkeys. Notably, numerous studies have honed in on the mitochondrial D-loop region, renowned for its remarkable variability and higher substitution rate within the mtDNA genome, rendering it an effective genetic marker for assessing genetic diversity in donkeys. Furthermore, genetic markers at the RNA/DNA level have emerged as indispensable tools for enhancing production and reproduction traits in donkeys. Traditional animal breeding approaches based solely on phenotypic traits, such as milk yields, weight, and height, are influenced by both genetic and environmental factors. To overcome these challenges, genetic markers, such as polymorphisms, InDel, or entire gene sequences associated with desirable traits in animals, have achieved widespread usage in animal breeding practices. These markers have proven increasingly valuable for facilitating the selection of productive and reproductive traits in donkeys. This comprehensive review examines the cutting-edge research on mitochondrial DNA as a tool for assessing donkey biodiversity. Additionally, it highlights the role of genetic markers at the DNA/RNA level, enabling the informed selection of optimal production and reproductive traits in donkeys, thereby driving advancements in donkey genetic conservation and breeding programs.

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Section: Genetic Markers Associated With Growth and Meat Production P...mentioning

confidence: 99%

Section: Why Have Genetic Markers Associated With Milk and Reproducti...mentioning

confidence: 99%

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Huang,

Khan,

Chai

et al. 2023

Animals

Self Cite

View full text Add to dashboard Cite

show abstract

“…In recent years, the exploration of genomic variation has emerged as a central focus of scientific inquiry in the fields of animal production and health regulation, as evidenced by numerous studies (4)(5)(6)(7)(8)(9)(10). This emphasis on genetic variation holds significant significance in our quest to comprehend the intricate interplay between genetic diversity and a wide array of phenotypic and economic traits exhibited by animals (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Advancements in copy number variation screening in herbivorous livestock genomes and their association with phenotypic traits

Liu,

Chen,

Huang

et al. 2024

Front. Vet. Sci.

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Copy number variations (CNVs) have garnered increasing attention within the realm of genetics due to their prevalence in human, animal, and plant genomes. These structural genetic variations have demonstrated associations with a broad spectrum of phenotypic diversity, economic traits, environmental adaptations, epidemics, and other essential aspects of both plants and animals. Furthermore, CNVs exhibit extensive sequence variability and encompass a wide array of genomes. The advancement and maturity of microarray and sequencing technologies have catalyzed a surge in research endeavors pertaining to CNVs. This is particularly prominent in the context of livestock breeding, where molecular markers have gained prominence as a valuable tool in comparison to traditional breeding methods. In light of these developments, a contemporary and comprehensive review of existing studies on CNVs becomes imperative. This review serves the purpose of providing a brief elucidation of the fundamental concepts underlying CNVs, their mutational mechanisms, and the diverse array of detection methods employed to identify these structural variations within genomes. Furthermore, it seeks to systematically analyze the recent advancements and findings within the field of CNV research, specifically within the genomes of herbivorous livestock species, including cattle, sheep, horses, and donkeys. The review also highlighted the role of CNVs in shaping various phenotypic traits including growth traits, reproductive traits, pigmentation and disease resistance etc., in herbivorous livestock. The main goal of this review is to furnish readers with an up-to-date compilation of knowledge regarding CNVs in herbivorous livestock genomes. By integrating the latest research findings and insights, it is anticipated that this review will not only offer pertinent information but also stimulate future investigations into the realm of CNVs in livestock. In doing so, it endeavors to contribute to the enhancement of breeding strategies, genomic selection, and the overall improvement of herbivorous livestock production and resistance to diseases.

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“…In the domain of livestock breeding, the pursuit of augmenting traits related to body size has emerged as a central objective, particularly in China, due to its substantial influence on meat production and carcass traits [10][11][12]. Recent research underscores the economic significance of vertebral count in determining carcass length, weight, and body size traits [10][11][12][13]. Variations in body size have emerged within and between domestic animal species or breeds during livestock evolution [14].…”

Section: Introductionmentioning

confidence: 99%

Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China

Khan,

Chen,

Huang

et al. 2024

Animals

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In livestock breeding, the number of vertebrae has gained significant attention due to its impact on carcass quality and quantity. Variations in vertebral traits have been observed across different animal species and breeds, with a strong correlation to growth and meat production. Furthermore, vertebral traits are classified as quantitative characteristics. Molecular marker techniques, such as marker-assisted selection (MAS), have emerged as efficient tools to identify genetic markers associated with vertebral traits. In the current review, we highlight some key potential genes and their polymorphisms that play pivotal roles in controlling vertebral traits (development, length, and number) in various livestock species, including pigs, donkeys, and sheep. Specific genetic variants within these genes have been linked to vertebral development, number, and length, offering valuable insights into the genetic mechanisms governing vertebral traits. This knowledge has significant implications for selective breeding strategies to enhance structural characteristics and meat quantity and quality in livestock, ultimately improving the efficiency and quality of the animal husbandry industry.

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Genotypes and haplotype combination of DCAF7 gene sequence variants are associated with number of thoracolumbar vertebrae and carcass traits in Dezhou donkey

Cited by 4 publications

References 29 publications

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys

Advancements in copy number variation screening in herbivorous livestock genomes and their association with phenotypic traits

Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China

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