Genotypic and antigenic identification of two new strains of spotted fever group rickettsiae isolated from China

Yu, Xue‐Jie; Jin, Yan; Fan, Mingyuan; Xu, Gang; Liu, Q; Raoult, Didier

doi:10.1128/jcm.31.1.83-88.1993

Cited by 120 publications

(56 citation statements)

References 17 publications

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“…mongolitimonae was described as a new subspecies of R. sibirica after being isolated from Hyalomma asiaticum in Inner Mongolia and China. It differed antigenetically and genotypically from the spotted fever group rickettsia (Yu et al, 1993) and presents specific characteristics: it causes multiple eschars, draining lymph nodes, a lymphangitis that extends from the inoculation eschar to the draining node. These symptoms can be presented alone or in combination.These clinical findings were observed in patients in the Mediterranean region where the parasite was isolated in 1996 (Fournier et al, 2005).…”

Section: Rickettsia Sibirica Mongolitimonaementioning

confidence: 99%

Scientific Opinion on Geographic Distribution of Tick-borne Infections and their Vectors in Europe and the other Regions of the Mediterranean Basin

2010

EFSA Journal

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This report is the second of a series of two technical assessments of the role of ticks in transmission of animal diseases and zoonoses in Eurasia. A previous published scientific opinion (EFSA Journal 2010; (8)8, 1703) focused on two diseases- Crimean-Congo haemorrhagic fever and African swine fever in Eurasia. The aim of this report is to provide an overview of the geographic distribution of tick species which have proven involvement in the transmission of pathogens causing animal diseases and zoonoses in Eurasia. The report provides maps of the region that display the occurrences of ticks and tick-borne pathogens. Systematic literature review of available publications for the last 10 years and other available literature from the experts were used in the retrieval of the geographical reported cases for the presence of ticks and tick borne pathogens. The report includes a description of the factors that influence the dynamics of the relevant tick species and identify possible high-risk areas in the EU for introduction, considering the biological and ecological characteristics of the ticks and their ability to adapt to new areas. Findings from this review have provided evidence of the extent of ticks and tick-borne diseases (TBDs) in geographical ranges and the existing risk areas that should be considered as baseline information to assess potential risk of these diseases. The report indicates the validity of using available literature to support the presence of ticks and TBDs without further predication using weather and other environmental factors associated with the ticks‟ survival. The report concluded that animal and human movement play more impact on the spread of the ticks and TBDs. Climate changes and flight pattern of migratory birds can influence the presence and spread of the ticks and TBDs, but have not been determined to be responsible for the widespread distribution of ticks

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Section: Rickettsia Sibirica Mongolitimonaementioning

confidence: 99%

Scientific Opinion on Geographic Distribution of Tick-borne Infections and their Vectors in Europe and the other Regions of the Mediterranean Basin

2010

EFSA Journal

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“…[30][31][32] This rickettsia was first isolated from Hyalomma asiaticum ticks collected in Mongolia in 1991. 33 In Europe, most of the cases occur in spring. In contrast with other tick-borne rickettsioses, in this disease the presence of enlarged lymph nodes, lymphangytis, and multiple eschars, is common, 32 these authors prompting to denominate this disease as LAR (lymphangitisassociated rickettsiosis).…”

Section: Tick-borne Rickettsiosesmentioning

confidence: 99%

Rickettsiosis in Europe

Blanco

Oteo

2006

Annals of the New York Academy of Sciences

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In Europe, rickettsioses are long-known infectious diseases. Until recently, it was thought that Mediterranean spotted fever due to Rickettsia conorii was the only tick-borne rickettsiosis in Europe. In the last decade new Rickettsia spp. have been implicated in human pathology (R. slovaca, R. sibirica mongolotimonae, R. helvetica). Furthermore, cases of infection due to flea-borne rickettsioses (R. typhi, R. felis) have been described. Finally, although no outbreak of epidemic typhus has been reported yet in central and southern Europe, we should be aware of the possibility of reemergence of this disease in Europe. Other rickettsioses exist that have not yet been implicated in human pathology. We should consider that climate changes and other factors could contribute to the emergence and reemergence of other new diseases.

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“…These include R. sibirica sensu stricto 4 and R. sibirica mongolitimonae, incorrectly named "R. mongolotimonae" previously. 5 Phylogenetically, these rickettsiae constitute a homogeneous cluster and are distinct from other Rickettsia species. [6][7][8] Initially, we have putatively considered R. sibirica mongolitimonae as a new species on the basis of a distinct serotype and specific epidemiological features.…”

Section: Introductionmentioning

confidence: 99%

Proposal to Create Subspecies of Rickettsia sibirica and an Emended Description of Rickettsia sibirica

Fournier

Zhu

et al. 2006

Annals of the New York Academy of Sciences

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The Rickettsia sibirica species is composed of isolates that are genotypically close but can be classified within two distinct serotypes, that is, R. sibirica sensu stricto and R. sibirica mongolitimonae (incorrectly named R. mongolotimonae). We investigated the possibility of classifying rickettsiae closely related to R. sibirica as R. sibirica subspecies, as proposed by the ad hoc Committee on Reconciliation of Approaches to Bacterial Systematics. For this, we first estimated the genotypic variability by using multilocus sequence typing (MLST), including the sequencing of five genes, and multispacer typing (MST) using three intergenic spacers, of five isolates and three tick amplicons of R. sibirica sensu stricto and six isolates of R. sibirica mongolotimonae. Then, we selected a representative of each MLST genotype and used mouse serotyping to estimate their degree of taxonomic relatedness. Among the 14 isolates or tick amplicons studied, 2 MLST genotypes were identified: (i) the R. sibirica sensu stricto type; and (ii) the R. sibirica mongolitimonae type. Representatives of the two MLST types were classified within three MST types and into two serotypes. Therefore, as isolates within the R. sibirica species are genotypically homogeneous but show MST genotypic, serotypic, and epidemio-clinical dissimilarities, we propose to modify the nomenclature of the R. sibirica species through the creation of subspecies. We propose the names R. sibirica subsp. sibirica subsp. nov. (type strain = 2-4-6, ATCC VR-541(T)), and R. sibirica subsp. mongolitimonae subsp. nov. (type strain = HA-91, ATCC VR-1526(T)). The description of R. sibirica is emended to accommodate the two subspecies.

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Genotypic and antigenic identification of two new strains of spotted fever group rickettsiae isolated from China

Cited by 120 publications

References 17 publications

Scientific Opinion on Geographic Distribution of Tick-borne Infections and their Vectors in Europe and the other Regions of the Mediterranean Basin

Scientific Opinion on Geographic Distribution of Tick-borne Infections and their Vectors in Europe and the other Regions of the Mediterranean Basin

Rickettsiosis in Europe

Proposal to Create Subspecies of Rickettsia sibirica and an Emended Description of Rickettsia sibirica

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