Genotypic Comparison of Invasive
            <i>Neisseria meningitidis</i>
            Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002

Whitney, Anne M.; Coulson, Garry B.; Gottberg, Anne von; Block, Colin; Keller, Nathan; Mayer, Leonard W.; Messonnier, Nancy E.; Klugman, Keith P.

doi:10.1128/jcm.00091-09

Cited by 17 publications

(14 citation statements)

References 19 publications

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“…32 An ST-23 clone of serogroup Y accounted for much of serogroup Y disease at this time in both Canada and the USA. 33,34 During the 1990s in Canada, the incidence of both serogroup B and serogroup C disease fell (from ~0.4 per 100,000 population and 0.65 per 100,000 population respectively in 1993, to ~0.2 per 100,000 population and 0.1 per 100,000 population respectively in 1998) but remained the two most frequently observed causes of IMD. 21 By the end of the 1990s, serogroup C incidence had risen once again (to ~0.4 per 100,000 population in 2000; overall rate of disease was 0.78 per 100,000 in 2000), with the have been group W135, supporting an increase in prevalence of W135 disease during this period.…”

Section: Resultsmentioning

confidence: 99%

“…The increase in the prevalence of serogroup Y is attributed to the emergence of an ST-23 clone of serogroup Y which accounts for much of serogroup Y IMD in both Canada and the USA. 33,34 While the incidence of all serogroups has fallen in the USA in recent years, serogroup Y continues to be responsible for approximately a third of endemic disease cases. In both the USA and Canada, serogroup A was a major cause of disease historically, but is now rare.…”

Section: Discussionmentioning

confidence: 99%

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The changing epidemiology of meningococcal disease in North America 1945–2010

Baccarini

Ternouth²,

Wieffer³

et al. 2013

Human Vaccines & Immunotherapeutics

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The changing epidemiology of meningococcal disease in North America 1945–2010

Baccarini

Ternouth²,

Wieffer³

et al. 2013

Human Vaccines & Immunotherapeutics

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“…A 2013 study on the 2009-2011 measles outbreak in South Africa recommended that all suspected measles cases should be managed and followed up to confirm the diagnosis. 31 Studies on meningococcal meningitis also demonstrated the importance of diagnosis and serogrouping in the effective surveillance and epidemiology of this disease, [37][38][39] as did studies on typhoid. 34,35,40,41 The finding in the present study that a diagnostic result was not obtained in a large percentage of NDSS cases is a cause for concern; this should be addressed in the reform of the South African NDSS.…”

Section: Discussionmentioning

confidence: 99%

Comparing laboratory surveillance with the notifiable diseases surveillance system in South Africa

Benson

Musekiwa

Blumberg

et al. 2017

International Journal of Infectious Diseases

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“…The lower frequency of serogroup Y and overall meningococcal carriage was reflected in a decrease in invasive meningococcal cases between 1998 and 2007 12. Serogroup Y disease has also been reported in South America, South Africa, Europe, and Israel 36,37. Most of the serogroup Y disease increase is associated with ST-23 and ST-167 clonal complexes 36,38.…”

Section: Changing Global Epidemiologymentioning

confidence: 94%

Meningococcal disease: changes in epidemiology and prevention

Chang¹,

Tzeng²,

Stephens³

2012

CLEP

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The human bacterial pathogen Neisseria meningitidis remains a serious worldwide health threat, but progress is being made toward the control of meningococcal infections. This review summarizes current knowledge of the global epidemiology and the pathophysiology of meningococcal disease, as well as recent advances in prevention by new vaccines. Meningococcal disease patterns and incidence can vary dramatically, both geographically and over time in populations, influenced by differences in invasive meningococcal capsular serogroups and specific genotypes designated as ST clonal complexes. Serogroup A (ST-5, ST-7), B (ST-41/44, ST-32, ST-18, ST-269, ST-8, ST-35), C (ST-11), Y (ST-23, ST-167), W-135 (ST-11) and X (ST-181) meningococci currently cause almost all invasive disease. Serogroups B, C, and Y are responsible for the majority of cases in Europe, the Americas, and Oceania; serogroup A has been associated with the highest incidence (up to 1000 per 100,000 cases) and large outbreaks of meningococcal disease in sub-Saharan Africa and previously Asia; and serogroups W-135 and X have emerged to cause major disease outbreaks in sub-Saharan Africa. Significant declines in meningococcal disease have occurred in the last decade in many developed countries. In part, the decline is related to the introduction of new meningococcal vaccines. Serogroup C polysaccharide-protein conjugate vaccines were introduced over a decade ago, first in the UK in a mass vaccination campaign, and are now widely used; multivalent meningococcal conjugate vaccines containing serogroups A, C, W-135, and/or Y were first used for adolescents in the US in 2005 and have now expanded indications for infants and young children, and a new serogroup A conjugate vaccine has recently been introduced in sub-Saharan Africa. The effectiveness of these conjugate vaccines has been enhanced by the prevention of person-to-person transmission and herd immunity. In addition, progress has been made in serogroup B-specific vaccines based on conserved proteins and outer membrane vesicles. However, continued global surveillance is essential in understanding and predicting the dynamic changes in the epidemiology and biological basis of meningococcal disease and to influence the recommendations for current and future vaccines or other prevention strategies.

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Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002

Cited by 17 publications

References 19 publications

The changing epidemiology of meningococcal disease in North America 1945–2010

The changing epidemiology of meningococcal disease in North America 1945–2010

Comparing laboratory surveillance with the notifiable diseases surveillance system in South Africa

Meningococcal disease: changes in epidemiology and prevention

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