Genotyping of C. psittaci in central area of Argentina

Frutos, María Celia; Monetti, Marina; Kiguen, Ximena; Venezuela, Raúl Fernando; Ré, Viviana Elizabeth; Cuffini, Cecilia

doi:10.1016/j.diagmicrobio.2012.06.027

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Standing against this evidence are folklore stories from South America that speak of a disease of influenza-like disease of man connected to intimate contact with “blue” birds 19 . To date, genetic data on South American C. psittaci strains is limited with one study from Argentina suggesting that the majority of human strains present belong to a genetically distinct C. psittaci clade (WC) than to the 6BC clade described in this study and elsewhere 20 . Extended studies of the genetic diversity of C. psittaci from wild Australian and South American psittacines will obviously be required to resolve this question.…”

Section: Discussionmentioning

confidence: 72%

Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen

Branley

Bachmann

Jelocnik

et al. 2016

Sci Rep

113

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Chlamydia psittaci is an avian pathogen and zoonotic agent of atypical pneumonia. The most pathogenic C. psittaci strains cluster into the 6BC clade, predicted to have recently emerged globally. Exposure to infected parrots is a risk factor with limited evidence also of an indirect exposure risk. Genome sequencing was performed on six Australian human and a single avian C. psittaci strain isolated over a 9 year period. Only one of the five human patients had explicit psittacine contact. Genomics analyses revealed that the Australian C. psittaci strains are remarkably similar, clustering tightly within the C. psittaci 6BC clade suggested to have been disseminated by South America parrot importation. Molecular clock analysis using the newly sequenced C. psittaci genomes predicted the emergence of the 6BC clade occurring approximately 2,000 years ago. These findings reveal the potential for an Australian natural reservoir of C. psittaci 6BC strains. These strains can also be isolated from seriously ill patients without explicit psittacine contact. The apparent recent and global spread of C. psittaci 6BC strains raises important questions over how this happened. Further studies may reveal whether the dissemination of this important zoonotic pathogen is linked to Australian parrot importation rather than parrots from elsewhere.

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Section: Discussionmentioning

confidence: 72%

Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen

Branley

Bachmann

Jelocnik

et al. 2016

Sci Rep

113

View full text Add to dashboard Cite

show abstract

“…In bordering countries, psittacosis prevalence studies have also been carried out. In central area of Argentina 21% (9/43) patients in whom psittacosis was suspected presented positive molecular results for C. psittaci [17]. In Venezuela, 8·3% (8/96) prevalence of C. psittaci infection was determine in individuals living in areas massive colonized by pigeons [18].…”

Section: Discussionmentioning

confidence: 99%

“…In Venezuela, 8·3% (8/96) prevalence of C. psittaci infection was determine in individuals living in areas massive colonized by pigeons [18]. Some authors believe that psittacosis is an underestimate disease, given that even a brief exposure can lead to a systemic infection, and testing for C. psittaci is often not included in routine microbiological diagnostic panels for pneumonia [17, 19]. Besides, it is important to keep in mind that individuals with mild cases may not seek medical attention contributing to the lack of epidemiological information of this disease [20].…”

Section: Discussionmentioning

confidence: 99%

Intersectoral action for health: preventing psittacosis spread after one reported case

et al. 2017

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Zoonotic diseases are a significant health threat for humans and animals. To better understand the epidemiology, etiology, and pathology of infectious agents affecting humans and animals combined approaches are needed. Here we describe an epidemiological investigation conducted by physicians and veterinarians after a reported case of psittacosis. Upon admission suffering from respiratory distress syndrome in a hospital and with a history of bird contact, a female patient was serologically diagnosed with psittacosis. After the case notification, veterinarians were able to investigate the source of infection by detecting Chlamydia psittaci in her pet cockatiel. The bird was hospitalized and successfully treated. In addition, the establishment where the pet bird was purchased was traced and through molecular techniques other birds intended to be sold as pets tested positive for C. psittaci. As a result, sanitary measures were applied and the establishment then was closed down. The birds intended for the pet commerce were treated and retested with negative molecular results for C. psittaci, thus avoiding disease propagation. Reliable data about zoonotic diseases can only be generated through the application of multidisciplinary approaches which take into account the epidemiological factors and interactions of humans, animals and their environments as an integrated system.

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“…However, few C. psittaci-specific surveillance and genotyping studies (and no genomes sequenced from the South Americas) exist to date [8]. Among the limited number of South American studies conducted, the majority only performed partial C. psittaci ompA characterisation [61][62][63][64][65], of which ompA genotype A was detected the most, followed by a lower frequency of genotypes B, E/B and WC. To contextualise these findings within a global phylogenetic framework and to estimate strain emergence, additional WGS of C. psittaci strains from South America is required, particularly from the clonal ST24 lineages and genetically distinct E/B and WC genotypes (in which little WGS data currently exists).…”

Section: What About C Psittaci Strains From South America?mentioning

confidence: 99%

Whole-genome sequencing of Chlamydia psittaci from Australasian avian hosts: A genomics approach to a pathogen that still ruffles feathers

et al. 2023

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Chlamydia psittaci is a globally distributed veterinary pathogen with zoonotic potential. Although C. psittaci infections have been reported in various hosts, isolation and culture of Chlamydia is challenging, hampering efforts to produce contemporary global C. psittaci genomes. This is particularly evident in the lack of avian C. psittaci genomes from Australia and New Zealand. In this study, we used culture-independent probe-based whole-genome sequencing to expand the global C. psittaci genome catalogue. Here, we provide new C. psittaci genomes from two pigeons, six psittacines, and novel hosts such as the Australian bustard (Ardeotis australis) and sooty shearwater (Ardenna grisea) from Australia and New Zealand. We also evaluated C. psittaci genetic diversity using multilocus sequence typing (MLST) and major outer membrane protein (ompA) genotyping on additional C. psittaci -positive samples from various captive avian hosts and field isolates from Australasia. We showed that the first C. psittaci genomes sequenced from New Zealand parrots and pigeons belong to the clonal sequence type (ST)24 and diverse ‘pigeon-type’ ST27 clade, respectively. Australian parrot-derived strains also clustered in the ST24 group, whereas the novel ST332 strain from the Australian bustard clustered in a genetically diverse clade of strains from a fulmar, parrot, and livestock. MLST and ompA genotyping revealed ST24/ompA genotype A in wild and captive parrots and a sooty shearwater, whilst ‘pigeon-types’ (ST27/35 and ompA genotypes B/E) were found in pigeons and other atypical hosts, such as captive parrots, a little blue penguin/Kororā (Eudyptula minor) and a zebra finch (Taeniopygia guttata castanotis) from Australia and New Zealand. This study provides new insights into the global phylogenomic diversity of C. psittaci and further demonstrates the multi-host generalist capacity of this pathogen.

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Genotyping of C. psittaci in central area of Argentina

Cited by 9 publications

References 10 publications

Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen

Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen

Intersectoral action for health: preventing psittacosis spread after one reported case

Whole-genome sequencing of Chlamydia psittaci from Australasian avian hosts: A genomics approach to a pathogen that still ruffles feathers

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