Genotyping of human adenoviruses circulating in Southwest India

Akhil, C.; Suresha, P. G.; Sabeena, Sasidharanpillai; Maity, Hindol; Arunkumar, Govindakarnavar

doi:10.1007/s13337-016-0337-5

Cited by 11 publications

(13 citation statements)

References 16 publications

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“…This prevalence was slightly higher than the previous findings in South Asia and Asia Pacific regions in which its prevalence was around 0.8% to 3.4%. 31,34,35 The molecular characteristics of AdV genotypes are only beginning to be addressed in Bangladesh. 31 Sequence analysis showed that AdV detected in this study belonged to four distinct species-AdV5 of AdV-C, AdV7 of AdV-B, AdV8 of AdV-D, and AdV41 of AdV-F.…”

Section: Discussionmentioning

confidence: 99%

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Sharif

Parvez

Haque

et al. 2020

Journal of Medical Virology

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Virus associated diarrhea remains one of the leading causes of children morbidity and mortality in Bangladesh. Human bocavirus (HBoV) has been reported as a potential pathogen of children's diarrhea worldwide. However, due to its frequent association with other gastroenteric pathogens, its role as diarrhea causative agent remains to be defined. This study focuses to detect the incidence of HBoV and adenovirus (AdV) and to determine the molecular and epidemiological characteristics of HBoV and AdV. Between January 2015 to January 2019, 290 fecal specimens were collected from diarrheal children in Bangladesh. All fecal specimens were tested for HBoV and AdV by conventional polymerase chain reaction and sequencing methods. HBoV was detected in 7.24% (21 of 290) of the stool samples, as a sole virus in 71.42% (15 of 21) of the positive samples. AdV was detected in 4.82% (14 of 290) of the samples. The most common clinical symptoms of HBoV infected patients were diarrhea (100%) and vomiting (57%). All of the isolates of HBoV were from HBoV1 and AdV were from AdV41, AdV5, AdV7, and AdV8. To the best of our knowledge, this is the first epidemiological and molecular analysis report of HBoV from clinical specimens in Bangladesh. In the future, more studies are needed to clarify the role of HBoV as diarrheal pathogens.

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Section: Discussionmentioning

confidence: 99%

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Sharif

Parvez

Haque

et al. 2020

Journal of Medical Virology

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“…Genotype 8 of HadV-D is reported to be most prevalent in ocular complications through all season with no differences in susceptibility in male or female [2] [9]. Contrarily, most HadV associated respiratory illness has been in cold months [2].…”

Section: Discussionmentioning

confidence: 99%

“…Contrarily, most HadV associated respiratory illness has been in cold months [2]. It is also notable that ocular-related HAdV is more prevalent than young children [2] [10].…”

Section: Discussionmentioning

confidence: 99%

“…It has been revealed that species B (serotypes 3 and 7), C (serotypes 1, 2, and 5), and E (serotype 4) are generally associated with respiratory diseases, whereas Adenoviruses in species F and subspecies D are often associated in gastroenteritis and viruses keratoconjunctivitis, respectively [2].…”

mentioning

confidence: 99%

“…Different receptors dealing with interaction of host and viruses as species A, B, C, E, and F Adenoviruses utilize CD46, DSG-2, or CAR receptors and generally cause respiratory disease in humans, while species D Adenovirus bind to α2-3-linked SA and GD1a glycans and has been associated with epidemic keratoconjunctivitis (EKC) which can progress to hemorrhagic conjunctivitis [3]. A recent study reported that species D can also be isolated in respiratory specimens as a dominant genotype [2].…”

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confidence: 99%

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Adenoviruses Type D in Patients with Respiratory Tract Infection Symptoms

Javid¹,

Moradi²,

Mohebbi³

et al. 2017

OALib

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Different Human Adenoviruses (HAdV) serotypes are associated with epidemic respiratory infections. The aim of this study was to detect HAdV from patients with respiratory symptoms and typing virus circulating in North of IRAN. Four hundred nasopharyngeal aspirate samples were obtained from patients with respiratory symptoms. Clinical data were collected. After DNA extraction, Polymerase Chain Reaction (PCR) was done for conserved Hexon region. Positive PCR products were used for sequencing grouping. 37 cases (9.2%) were positives. Clinical symptoms as cough (73%), body (67/6%), and fever (64/9%) were found in 35 infected patients (94/5%) and two patients (15/5%) had no symptoms. All samples were belonged to HAdV of species D (HAdV-8). Prevalence of respiratory adenovirus infection in our area is consistent with other studies in Iran and ocular type of HAdV8 was the frequent adenovirus serotype circulating in acute respiratory disease in Golestan province.

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Upsurge in hospitalization of pediatric patients with severe acute respiratory infections in Kolkata and surrounding districts caused by recombinant human respiratory adenovirus type B 7/3

Majumdar

Saha

Chatterjee

et al. 2023

Journal of Medical Virology

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Globally, different genotypes of human adenoviruses are associated with outbreaks of acute respiratory infection (ARI) though such evidence is lacking from India. In the present study, we report a sudden increase in the positivity of respiratory adenovirus among hospitalized children with ARI from Kolkata and the surrounding districts of West Bengal, India, from December 2022 to date. A sharp rise in the positivity rate of respiratory adenovirus was found which ranged from 22.1% in early December 2022 to 52.6% in mid-March 2023. The overall positivity was 40.4% during the period and children in the 2 to <5 years (51.0%) age group were mostly affected. Single infection with adenovirus was found in 72.4% of cases while co-infection with rhinovirus was the maximum (9.4%).Around 97.5% of positive cases required hospitalization. Cough, breathlessness, and wheeze were the most common clinical features among positive patients. Phylogenetic analysis of the hexon and fiber gene of all the sequenced strains revealed HAdV-B 7/3 recombination with more than 99% homology within themselves. This report of a respiratory adenovirus outbreak in West Bengal, India causing severe illness in the pediatric population underscores the need for regular monitoring of the circulating strains.

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Genotyping of human adenoviruses circulating in Southwest India

Cited by 11 publications

References 16 publications

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Adenoviruses Type D in Patients with Respiratory Tract Infection Symptoms

Upsurge in hospitalization of pediatric patients with severe acute respiratory infections in Kolkata and surrounding districts caused by recombinant human respiratory adenovirus type B 7/3

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