Genotyping of <i>κ-casein</i> and <i>β-lactoglobulin</i> genes in native cattle from Barishal region of Bangladesh

Akter, Salma; Anower, A. K. M. M.; Hossain, Mridha Md. Kamal; Alim, Md. Abdul; Jahan, Nusrat; Bhuyan, Anjuman Ara; Salimullah, Md.; Alam, Jahangir

doi:10.1080/10495398.2020.1781145

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Moreover, Sitkowska et al [14] and [17] reported that the AB genotype was most frequent (44% and 50.32%, respectively) in the investigated population of PHF. Different results were obtained by Akter et al [18], who investigated the polymorphism in the PAEP gene in Bangladesh cattle, reporting that the genotype BB was the most frequent (66%), while AA and AB were at a similar level (16% and 18% respectively). They did not, however, provide information on cattle breed, indicating that cows were selected randomly, which may suggest that different breeds might have been subjected to the test.…”

Section: Allele and Genotype Frequencymentioning

confidence: 65%

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Kolenda

Sitkowska

2021

Animals

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The aim of the present study was to evaluate the genotype and allele frequencies of 24 polymorphisms in casein alpha S1 (CSN1S1), casein alpha S2 (CSN1S2), beta-casein (CSN2), kappa-casein (CSN3), and progestagen-associated endometrial protein (PAEP) genes. The study included 1900 Polish Black and White Holstein-Friesian dairy cows that were subjected to genotyping via microarrays. A total of 24 SNPs (Single Nucleotide Polymorphisms) within tested genes were investigated. Two CSN1S1 SNPs were monomorphic, while allele CSN1S1_3*G in CSN1S1_3 SNP dominated with a frequency of 99.39%. Out of seven CSN2 SNPs, four were polymorphic; however, only for CSN2_3 all three genotypes were detected. Only three out of nine SNPs within CSN3 were monomorphic. Three PAEP SNPs were also found to be polymorphic with heterozygotes being most frequent. Hardy–Weinberg equilibrium (HWE) was observed for eight variants. It was shown that only CSN3_6 was not in HWE. The fact that many of investigated SNPs were monomorphic may suggest that in the past the reproduction program favored one of these genotypes. SNPs that are included in commercially available microarrays should be monitored in relation to changes in their frequencies. If a SNP has turned monomorphic, maybe it should be considered for removal from the microarray.

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Section: Allele and Genotype Frequencymentioning

confidence: 65%

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Kolenda

Sitkowska

2021

Animals

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Influence of β-casein genotype on Cheddar cheese making and ripening

Gai,

Waldron,

Uniacke-Lowe

et al. 2024

International Dairy Journal

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The study of capa-casein gene polymorphism in cattle populations created on the maternal basis of the Lebedyn breed

Ladyka,

Malikova,

Skliarenko

et al. 2024

Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva

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Scientifc studies were conducted in breeding herds of the Ukrainian Brown dairy breed and the Sumy inbred type of the Ukrainian Black-and-White dairy breed to investigate the peculiarities of capa-casein gene polymorphism. What these breeds have in common is their descent from the same autochthonous breed, the Lebedyn breed. The process of creating these breeds was distinguished by the use of sires of diﬀerent breeds, namely Swiss and Holstein. Genotyping of 60 cows (30 of each breed) was carried out. The polymorphism of the capa-casein gene was determined in the genetic laboratory of the Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine using molecular biological analysis of allele recognition by real-time polymerase chain reaction (PCR). It was found that Ukrainian brown dairy cows were distinguished by a higher frequency of the desired homozygous BB genotype, it was 40%. A higher frequency of homozygous genotype AA was characterised by cows of Sumy inbred type of Ukrainian Black-andWhite dairy breed (68 %). The proportion of heterozygous genotype AB was higher in cows of the Ukrainian Brown dairy breed (48 %). The frequency of the B allele in animals of the Ukrainian Brown dairy breed was 0.64, while in cows of the Sumy inbred type of the Ukrainian Black-and-White dairy breed it was only 0.20. Correspondingly, a higher frequency of allele A was observed in animals of the Sumy inbred type of the Ukrainian Black-and-White dairy breed (0.80). The ratio of allele frequencies in the animals of the studied breeds was, respectively, 1.8 times and 4 times. The actual proportion of heterozygotes was lower than expected in animals of the Sumy inbred type of the Ukrainian Black-and-White dairy breed. On the contrary, the actual heterozygosity was higher than expected in cows of the Ukrainian Brown dairy breed. The results of the analysis of the breeding data of the sires from which the animals in the experimental farms originated indicate that a small proportion of them were evaluated for the capa-casein genotype. Of the sires evaluated, only 44% of Holstein sires had the BB genotype, while 67% of Swiss sires had the BB genotype. Considering the results of the research, we believe that the formation of herds with the BB genotype is possible in the populations of both studied breeds. In the future, it will be possible to create quickly enough breeding herds with specifed genetic parameters at the request of processing enterprises. For this purpose, it is necessary to use sires that have the BB genotype for the capa-casein gene. Key words: breed, milk yield, fat content, protein content, capa-casein, genotype, allele.

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Genotyping of κ-casein and β-lactoglobulin genes in native cattle from Barishal region of Bangladesh

Cited by 3 publications

References 24 publications

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Influence of β-casein genotype on Cheddar cheese making and ripening

The study of capa-casein gene polymorphism in cattle populations created on the maternal basis of the Lebedyn breed

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