Gentamicin concentrations in synovial fluid obtained from the tarsocrural joints of horses after implantation of gentamicin-impregnated collagen sponges

Ivester, Kathleen; Adams, Stephen B.; Moore, George E.; Sickle, David C. Van; Lescun, Timothy B.

doi:10.2460/ajvr.67.9.1519

Cited by 36 publications

(24 citation statements)

References 21 publications

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“…This is in contrast to studies 8,13 performed with gentamicin in horses. Blood, synovial fluid of control joints, and specimens of organs had negative results.…”

Section: Discussioncontrasting

confidence: 80%

“…4,5,[7][8][9][10][11] Additionally, some of these drugs have been tested in controlled-release formulations to decrease the number of arthrocentesis procedures needed for treatment. 4,12,13 However, some of these drugs can induce tissue irritation, 8,14,15 and their antimicrobial spectrum does not always match the microorganisms isolated from cattle. 4,16 Doxycycline is a semisynthetic antimicrobial of the tetracycline group.…”

mentioning

confidence: 99%

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Intra-articular administration of doxycycline in calves

Haerdi-Landerer

Suter²,

Steiner³

2007

ajvr

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Objective-To evaluate local tissue compatibility of doxycycline hyclate (DOX) in antebrachiocarpal joints of calves. Animals-10 healthy calves between 80 and 110 kg. Procedures-Calves were assigned to 2 treatment groups. Calves in groups DOX(low) and DOX(high) were administered 5 and 10 mg of DOX, respectively, locally in 1 antebrachiocarpal joint. The contralateral joint served as a control joint and was injected with 0.9% NaCl solution. General and local clinical findings were scored. Several variables were assessed in blood and synovial fluid for 9 days. Calves were euthanatized and pathologic changes and drug residues evaluated. Results-Throughout the study, none of the calves had clinical changes or abnormal hematologic values. Significant differences between treatment and control joints were evident only for matrix metalloproteinases at 0.5 hours after injection, with less activity for the DOX-treated joints in both treatment groups. Values for all synovial fluid variables, except nitric oxide, increased significantly during the first 12 to 72 hours after arthrocentesis in control and DOX-treated joints. Histologic examination revealed minimal infiltration of inflammatory cells independent of the treatment. No drug residues were detected 9 days after arthrocentesis in any tissues obtained from the liver, kidneys, fat, and skeletal muscles. Conclusions and Clinical Relevance-DOX had excellent intra-articular compatibility in healthy calves. Arthrocentesis induced a mild transient increase of inflammatory mediators in the synovial fluid. Significant decreases in matrix metalloproteinase activity in DOX-treated joints may indicate a potential chondroprotective effect of DOX.

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“…This is in contrast to studies 8,13 performed with gentamicin in horses. Blood, synovial fluid of control joints, and specimens of organs had negative results.…”

Section: Discussioncontrasting

confidence: 80%

mentioning

confidence: 99%

Intra-articular administration of doxycycline in calves

Haerdi-Landerer

Suter²,

Steiner³

2007

ajvr

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“…Currently, local antimicrobials can be delivered by serial intra‐articular injections, serial regional limb perfusions, continuous infusion pumps, or intra‐articular placement of antimicrobial impregnated implants 1,5,8–12 . Although effective, serial intra‐articular injections and regional limb perfusions can be technically challenging in a limb with secondary cellulitus, 1 and unfeasible in the proximal aspect of the limb of horses where tourniquet placement is not possible.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, Plaster of Paris beads have not been assessed in vivo in horses so the erosive effects on cartilage and synovium are unknown. A pharmacokinetic study on the use of gentamicin impregnated collagen sponges concluded that they do not offer any direct advantage over direct intra‐articular injection of the same drug 12 . Therefore a need exists for the development of a new absorbable implant that ideally would be made from a bioabsorbable matrix and would release antimicrobial concentrations within the therapeutic range for an extended period.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Ferric‐Hyaluronate Implants for Delivery of Amikacin Sulfate to the Tarsocrural Joint of Horses

et al. 2009

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“…Many bioabsorbable carriers have been investigated including protein materials, bone graft materials and substitutes, and synthetic polymers. Protein materials including collagen sponge, 11,12 fibrinogen, 13 gelatin, 14,15 albumin, ferric‐hyaluronate, 16 R‐gel ™ , 17 and autologous blood clot have all been described but suffer from very short‐term antibiotic release over hours to days 9 . Bone graft materials and substitutes for antibiotic delivery and release include calcium sulfate (plaster of Paris), 18,19 calcium sulfate wrapped in porcine small intestinal submucosa, 20 calcium phosphate cement, 10,21,22 hydroxyapatite cement, 18,23 calcium sulfate and hydroxyapatite combination, 24 bioactive glass, and cancellous bone graft 9 .…”

mentioning

confidence: 99%