1991
DOI: 10.1007/bf00173656
|View full text |Cite
|
Sign up to set email alerts
|

Gentamicin-induced alterations of succinic dehydrogenase activity in the organ of Corti as revealed by non-decalcified frozen sections of the guinea pig's cochlea

Abstract: The distribution of succinic dehydrogenase (SDH) activity and the changes of SDH activity after injection of gentamicin (GM) were observed in the organ of Corti using non-decalcified frozen sections of the guinea pig's cochlea. The distribution of SDH activity was found to increase from the apex to the basal turn. At each turn, SDH activity of the inner hair cells, the inner supporting cells and the nerve endings surrounding the supporting cell and on the hair cells presented a greater activity than that found… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
8
0

Year Published

1999
1999
2012
2012

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(8 citation statements)
references
References 30 publications
0
8
0
Order By: Relevance
“…For instance, when succinate, one of the intermediate products in the citric acid cycle, is included in the incubation medium, SDH will catalyze its oxidation to fumarate [Clarke et al, 1989;Spector, 1975;Vosteen, 1960] and the liberated hydrogen ion will reduce the electron-accepting tetrazolium salt to an insoluble, blue formazan [Koide et al, 1964;Spoendlin and Balogh, 1963;Vosteen, 1960;Yang et al, 1990]. Thus, the density of the reaction product formed is proportional to a cell's oxygen consumption and energy production and can be used to infer aerobic metabolic activity [Chalmers et al, 1992;Peter et al, 1972;Spoendlin and Balogh, 1963;Stoward and Ploem, 1982;Vosteen, 1960;Yang and Han, 1991;Yang et al, 1990].…”
Section: Introductionmentioning
confidence: 99%
See 4 more Smart Citations
“…For instance, when succinate, one of the intermediate products in the citric acid cycle, is included in the incubation medium, SDH will catalyze its oxidation to fumarate [Clarke et al, 1989;Spector, 1975;Vosteen, 1960] and the liberated hydrogen ion will reduce the electron-accepting tetrazolium salt to an insoluble, blue formazan [Koide et al, 1964;Spoendlin and Balogh, 1963;Vosteen, 1960;Yang et al, 1990]. Thus, the density of the reaction product formed is proportional to a cell's oxygen consumption and energy production and can be used to infer aerobic metabolic activity [Chalmers et al, 1992;Peter et al, 1972;Spoendlin and Balogh, 1963;Stoward and Ploem, 1982;Vosteen, 1960;Yang and Han, 1991;Yang et al, 1990].…”
Section: Introductionmentioning
confidence: 99%
“…As with other tissue systems, the main source of energy in the cochlea is the oxidation of glucose by glycolysis and the subsequent production of ATP by the citric acid cycle [Yang and Han, 1991]. If the oxygen supply is insufficient or if metabolic pathways involved in oxidative phosphorylation are blocked, energy can be supplied by anaerobic breakdown of carbohydrates for a limited period of time [Spoendlin andBalogh, 1963: Vosteen, 1960].…”
Section: Introductionmentioning
confidence: 99%
See 3 more Smart Citations