Gentamicin induced Anaphylaxis, a case report

Henao, Catalina María Gómez; Morales, C; Villa, Ricardo Cardona; Henao, Ana María Celis

doi:10.1186/1939-4551-8-s1-a269

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Christiansen el at describes a patient previously exposed to gentamicin in bone cement with hypotension, generalized erythema, and angioedema a few minutes after IV gentamicin also used for surgical prophylaxis [20]. Henao et al report a case of urticaria, angioedema, and respiratory distress after multiple days of IM gentamicin for a superinfected third-degree burn [21]. Jung et al describe a patient with a history of generalized urticaria within 1 h after administration of an IV aminoglycoside who experienced initial ear-itching and facial erythema followed by generalized urticaria, dyspnea, chest discomfort, and dizziness 10 min after intradermal testing with streptomycin at a concentration of 1 mg/mL [22].…”

Section: Ige-mediated Reactionsmentioning

confidence: 99%

“…There are no validated skin tests for the diagnosis of immediate hypersensitivity to aminoglycosides. There are case reports of patients who experienced immediate clinical hypersensitivity reactions to gentamicin, tobramycin, neomycin, and streptomycin in which IgE-mediated allergy was confirmed by positive SPT [19][20][21]23]. If SPTs are negative, intradermal tests (IDTs) can be performed with nonirritating concentrations.…”

Section: Immediate-type Skin Testingmentioning

confidence: 99%

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Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Dilley

Geng

2021

Clinic Rev Allerg Immunol

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Hypersensitivity reactions including IgE-mediated and delayed cell-mediated reactions to aminoglycosides, clindamycin, linezolid, and metronidazole are rare. For aminoglycosides, allergic contact dermatitis is the most frequent reaction for which patch testing can be a useful step in evaluation. For clindamycin, delayed maculopapular exanthems are the most common reactions. There are case reports of clindamycin associated with drug rash with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), acute febrile neutrophilic dermatosis, and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). For linezolid, cases of hypersensitivity were exceedingly rare and included urticaria, angioedema, anaphylaxis, delayed rashes, and DRESS. For metronidazole, only rare cases were found across a broad spectrum of reactions including allergic contact dermatitis, fixed drug eruption, angioedema, anaphylaxis, serum sickness-like reaction, SJS/TEN, AGEP, SDRIFE, and a possible case of DRESS. IgE-mediated reactions and anaphylaxis to these types of antibiotics are uncommon, and reports of skin testing concentrations and desensitization protocols are largely limited to case reports and series. Non-irritating skin testing concentrations have been reported for gentamycin, tobramycin, and clindamycin. Published desensitization protocols for intravenous and inhaled tobramycin, oral clindamycin, intravenous linezolid, and oral and intravenous metronidazole have also been reported and are reviewed.

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Section: Ige-mediated Reactionsmentioning

confidence: 99%

Section: Immediate-type Skin Testingmentioning

confidence: 99%

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Dilley

Geng

2021

Clinic Rev Allerg Immunol

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“…Overall, allergic reactions to aminoglycosides reported in the literature are rare. Aminoglycosides come in multiple dosage forms, including topical, parenteral, and inhaled, and there have been reports of reactions from each dosage form, some being localized reactions, and others being systemic reactions [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59]. Below and in Table 2, Table 3 and Table 4 is a summary of the reactions caused by gentamicin, tobramycin, and amikacin.…”

Section: Documented Allergic Reactionsmentioning

confidence: 99%

“…There are reports of anaphylaxis with both gentamicin and amikacin, and all of these cases result from parenteral use of the drug (Table 3) [50,51,52,53,54,55]. Two of the case reports involving gentamicin identified that the patient had previous been treated with at least one aminoglycoside, which could have caused the sensitization.…”

Section: Documented Allergic Reactionsmentioning

confidence: 99%

Aminoglycoside Allergic Reactions

et al. 2019

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Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.

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Development of ELISA and chemiluminescence enzyme immunoassay for quantification of histamine in drug products and food samples

Zhou

Eremin

et al. 2020

Anal Bioanal Chem

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Gentamicin induced Anaphylaxis, a case report

Cited by 6 publications

References 2 publications

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Aminoglycoside Allergic Reactions

Development of ELISA and chemiluminescence enzyme immunoassay for quantification of histamine in drug products and food samples

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