Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?

Balakumar, Pitchai; Rohilla, Ankur; Thangathirupathi, Arunachalam

doi:10.1016/j.phrs.2010.04.004

Cited by 245 publications

(207 citation statements)

References 86 publications

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“…Gentamicin was first isolated from Micromonospora purpurea, gram-positive bacteria widely present in water and soil (3). Because of its effectiveness and the low rate of bacterial resistance, GM is often considered as a drug of choice to treat life-threatening infections such as sepsis (15,20).…”

Section: Introductionmentioning

confidence: 99%

“…Because of its effectiveness and the low rate of bacterial resistance, GM is often considered as a drug of choice to treat life-threatening infections such as sepsis (15,20). It acts by irreversibly binding the 30S subunit of the bacterial ribosome, causing misreading of t-RNA, leaving the bacterium unable to synthesise proteins vital to its growth (3). Like all aminoglycosides, when gentamicin is administered orally, it is not systemically active because GM is not absorbed to any appreciable extent from the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Experimental gentamicin-induced nephrotoxicity in the sheep

Fartashvand

Mousavi

Hajisadeghi

2014

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to investigate the nephrotoxic effects of gentamicin in adult male sheep, and to identify the earliest signs of toxicity and the extent of clinical and biochemical changes. Twenty clinically healthy yearling male Iranian fattailed sheep were injected with gentamicin sulfate at a daily dose of 80 mg/kg for 9-10 d when nephrotoxicosis was induced. Blood samples were collected weekly before and after induction of nephrotoxicosis. Gentamicin-induced nephrotoxicity was characterised by increased creatinine and urea levels in serum, electrolyte imbalances, occurrence of albuminuria, and renal dysfunction. Significant elevation in respiratory and heart rates were observed one week after treatment (P < 0.05). There was a noticeable increase in water consumption, lethargy, and loss of appetite in treated sheep. There were significant correlations between serum creatinine and potassium (P = 0.004, r = 0.759), sodium (P = 0.017, r = 0.501), and urea (P = 0.021, r = 0.617) levels. Additionally, significant negative correlations between serum total protein and albumin and creatinine (P = 0.023, r = -0.484) and urea (P = 0.036, r = -0.381) were found. At necropsy, the kidneys were pale, swollen, and wet on the cut surface, especially perirenal tissues and ureters were oedematous. These findings confirmed the previous reports in other species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental gentamicin-induced nephrotoxicity in the sheep

Fartashvand

Mousavi

Hajisadeghi

2014

Bulletin of the Veterinary Institute in Pulawy

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“…Eur. 5,2007). The ethanolic extract of Camellia Sinensis (commercial sample from "Josif Pancic", Pancevo, Serbia) were obtained after evaporation to the dryness in vacuo under 40ºC and extraction yield was 25%.…”

Section: A Te Ri Al S a Nd M E T Hods P R E Pa R At I O N Of E T Hmentioning

confidence: 99%

“…Gentamicin-induced nephrotoxicity is an animal model for study of acute kidney failure in experimental research (3). Although the mechanism by which gentamicin causes nephrotoxicity remains unclear, proposed pathological mechanisms include induction of oxidative stress, apoptosis, necrosis, elevation of endothelin I and increase of monocyte/macrophages infiltration (3)(4)(5). Getamicininduced nephrotoxicity is clinically characterized by increased serum creatinine and blood urea nitrogen and decreased glomerular filtration rate (2,3) and morphologically by focal necrosis and apoptosis in tubular epithelium with extensive peritubular cell inflammation (2).…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Green Tea Extract in Gentamicin-Induced Acute Renal Failure in Rats / Povoljni efekti ekstrakta zelenog čaja na akutnu bubrežnu insuficijenciju uzrokovanu gentamicinom kod pacova

Veljković¹,

Ilić²,

Stojiljković³

et al. 2015

Acta Facultatis Medicae Naissensis

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The aim of this study was to investigate whether green tea extract has beneficial effect on gentamicin-induced acute renal failure. The investigation was conducted on thirty-two Wistar rats divided into four groups of 8 animals each. Control (C) group received normal saline. GT group received green tea extract orally, 300mg/kg. GM group received gentamicin intraperitoneally, 100mg/kg and GT+GM group received both gentamicin and green tea extract.Histological sections of kidney in GM group revealed necrosis of proximal tubules, vacuolization of cytoplasm and massive mononuclear inflammatory infiltrates in interstitium. Coadministration of green tea with gentamicin had renoprotective effect and showed only mild infiltrations, normal glomeruli and alleviated tubular degeneration. Analysis of biochemical parameters showed significantly higher urea and creatinine serum concentrations in GM group in comparison with C group and GT+GM group (p<0.001). Plasma lipid peroxidation biomarker MDA was significantly higher in GM group than those in C group (p<0.001), whereas the values for GT+GM group were significantly lower than MDA recorded for GM group (p<0.001).Beneficial effects of green tea on gentamicin-induced nephrotoxicity is explained through decrease of oxidative stress and lipid peroxidation.Our results indicate that green tea administration has nephroprotective effect on oxidative stress and acute renal failure caused by gentamicin.

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“…Gentamicin has been confirmed to increase the generation of reactive oxygen species in the kidney which leads to renal anatomical and physiological damage. Furthermore, gentamicin treated rat kidneys are more prone to oxidative damage due to the generation of reactive oxygen species there by increased levels of lipid peroxidation and decreased levels of anti oxidant enzymes in gentamicin treated rat kidney [2] . Even though, gentamicin is having ototoxicity and nephrotoxicity still, it is using in clinical practices because of its potent bactericidal activity and less resistance, in those conditions a supportive therapy must be given to the patient to protect from the nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Reddy¹,

Kumar²,

Swamy³

et al. 2014

Phcog J.

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Objective: To evaluate the potential nephroprotective and antioxidant activity of hydroalcoholic Cissampelos pareira (C. pareira) whole plant extract using gentamicin-induced rats. Methods: For studying acute toxicity study, single oral dose of 2g/kg hydroalcoholic extract of C. pareira was evaluated in rats by oral gavage. The nephroprotective activity was evaluated using gentamicin-induced model in rats. In-vitro antioxidant activity was evaluated by using DPPH assay and reducing power assay. In-vivo antioxidant activity was evaluated by using glutathione and lipid peroxidation estimations in gentamicin-induced rats. Hydroalcoholic C. pareira whole plant extract was given at a dose of 200 and 400 mg/kg p.o. Results: For acute toxicity testing rats administered with the extract at a dose 2 g/ kg. the result showed no toxicity. Hydroalcoholic C. Pareira whole plant extract (200 and 400 mg/kg p.o) significantly decrease the elevated urinary glucose levels in the urine, decrease the elevated urea and creatinine levels in blood and increase the urinary creatinine levels in gentamicin-induced nephrotoxic rats. The extract had shown significant dose dependent increase in the DPPH and reducing power activity. There were a dose dependent decreasing and increasing of lipid peroxidation, glutathione levels in hydoalcoholic extract treated groups respectively. Conclusion: This study exhibits that hydroalcoholic C. pareira whole plant extract poses nephroprotective activity which may be due to its antioxidant activity.

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Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?

Cited by 245 publications

References 86 publications

Experimental gentamicin-induced nephrotoxicity in the sheep

Experimental gentamicin-induced nephrotoxicity in the sheep

Beneficial Effects of Green Tea Extract in Gentamicin-Induced Acute Renal Failure in Rats / Povoljni efekti ekstrakta zelenog čaja na akutnu bubrežnu insuficijenciju uzrokovanu gentamicinom kod pacova

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

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