Gentamicin-loaded discs and microspheres and their modifications: characterization and in vitro release

Naraharisetti, Pavan Kumar; Lew, Magdeleine Duan Ning; Fu, Yin‐Chih; Lee, Dong Hoon; Wang, Chi-Hwa

doi:10.1016/j.jconrel.2004.10.016

Cited by 79 publications

(66 citation statements)

References 28 publications

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“…The duration of the stable release phase in polymer matrixes highly depends on the type of polymer used (55). It appears that polymers degrade via surface erosion, bulk degradation or both mechanisms.…”

Section: Drug Release Ratementioning

confidence: 99%

Controlled Release of Drugs for Management of Pulpitis

Jaberi-Ansari¹,

Ekrami²,

Nojehdehian³

2014

Avicenna J Dent Res

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Section: Drug Release Ratementioning

confidence: 99%

Controlled Release of Drugs for Management of Pulpitis

Jaberi-Ansari¹,

Ekrami²,

Nojehdehian³

2014

Avicenna J Dent Res

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“…Bu sistemler, belli koşullarda şiştiklerinde biyomolekülün, jelden dışa-rıya difüzlenmesiyle molekülü salacak şekilde üretilebi-lirler. İlacı hidrojellerin üzerine veya içerisine immobilize etmek için fiziksel tutuklama, elektrostatik etkileşimler, fiziksel adsorpsiyon ve kimyasal bağlanma gibi birçok yöntem kullanılabilir [7]. Her bir tekniğin avantaj ve dezavantajları vardır.…”

Section: Introductionunclassified

Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

Ayhan¹

2014

Turk J Bioch

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Objective: In the work presented, synthesis of PEG based hydrogels, characterization of synthesized hydrogels and usage of these hydrogels in controlled drug release systems were studied. Methods: Synthesis of PEG based hydrogels having different properties was done by free radical photopolymerization by using a photoinitiator . In this stage because of their biocompatibility, poly ethylene glycol Diacrylate (PEG-DA) as macromer; ethylene glycol dimetacrylate (EGDMA) as cross-linker and 2,2 dimetoxy-2 phenylacetophenon (DMPA) as photoinitiator were used. The macromer amounts of 30, 50 and 100%, cross-linker ratio of 0.25, 1.0 and 3% and photoinitiator ratio of 0.1, 0.5 and 1% by weight were selected. In this scope, dynamic swelling behaviour of hydrogels and their suitability for controlled drug release were tested. The surface characterization of the hydrogels was performed by Attenuated Total Reflectance-Fourier Transfer Infrared Spectroscopy (ATR-FTIR) spectrums. The drug release experiments of dry polymer disks with known weight and known loaded drug amount were performed in pH 7.4 and 1.2 buffer solutions with set ionic strengths, in shaking incubator at 37°C constant temperature with a shaking speed of 100 rpm. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: A decrease in swelling degree of hydrogel was observed with an increase in macromer ratio. In the ATR-FTIR spectrums, O-H tension, C-H tension, C=O tension, C-O tension vibration bands which can be said to be a characteristic of PEG-DA hydrogels were observed. The rate of drug release in pH 1.2 was observed to be much faster than pH 7.4 for both types of hydrogels. The transport mechanism in hydrogels was determined by a widely used semi-empirical formula. It was observed that selected drug-loaded hydrogels were effective on inhibition of the reproduction of both bacteria. Conclusion: In the work presented, all of the hydrogels synthesized were found compatible for the controlled drug delivery. Key Words: Photopolymerization, hydogels, controlled drug delivery; PEG. Conflict of Interest:The authors declare no conflict of interest. ÖZETAmaç: Sunulan araştırma kapsamında; PEG bazlı hidrojellerin sentezi, elde edilen hidrojellerin karakterizasyonu ve bu hidrojellerin kontrollü ilaç salım sistemlerinde kullanımlarının incelenmesi amaçlanmıştır. Metod: Farklı özelliklere sahip PEG bazlı hidrojellerin fotopolimerizasyon yöntemi ile fotobaşlatıcı kullanılarak serbest-radikal fotopolimerizasyonuyla sentezi gerçekleştirilmiştir. Bu aşamada yüksek biyouyumluluğu nedeniyle poli(etilenglikol) diakrilat (PEGDA) makromeri; çapraz bağlayıcı olarak etilen glikol dimetakrilat (EGDMA), fotobaşlatıcı olarak ise 2,2-dimetoksi-2-fenilasetofenon (DMPA) kullanılmıştır. Makromer oranı ağırlıkça %30, 50 ve 100; çapraz bağlayıcı oranı ağırlıkça %0.25, 1.0, 3.0; fotobaşlatıcı oranı ağırlıkça %0.1, 0.5 ve 1 değerlerinde değiştirilerek bileşen mikt...

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“…6 However, the microencapsulation of water-soluble drugs presenting low molecular weight is a difficult task because the formulations usually showed low encapsulation efficiencies and rapid release profiles due to the affinity of the drug by the aqueous medium. 7,8 Spray-drying and multiple emulsions have been widely employed to prepare polymeric microparticles for either water soluble or water insoluble drugs using hydrophilic and hydrophobic polymers. [9][10][11][12] There are few reports in the literature dedicated to the microenhere are few reports in the literature dedicated to the microencapsulation of sodium alendronate or other bisphosphonates.…”

Section: Introductionmentioning

confidence: 99%

High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles

Cruz¹,

Assumpção²,

Guterres³

et al. 2009

Quím. Nova

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Recebido em 16/5/08; aceito em 12/12/08; publicado na web em 11/5/09The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit ® S100 and Methocel ® F4M or Methocel ® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.

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Gentamicin-loaded discs and microspheres and their modifications: characterization and in vitro release

Cited by 79 publications

References 28 publications

Controlled Release of Drugs for Management of Pulpitis

Controlled Release of Drugs for Management of Pulpitis

Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles

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