Gentamicin Resistance Among Gram-negative Bacillary Blood Isolates in a Hospital With Long-term Use of Gentamicin

Mylotte, Joseph M.

doi:10.1001/archinte.1987.00370090118020

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Only a few studies have reported resistance data concerning Gram‐negative bloodstream infections [6,19,22–24]. Among these, Mylotte observed similar trends in resistance [24]. In his study, performed between 1977 and 1985, the yearly GM resistance rate of Gram‐negative bloodstream isolates was 13.2% (range 6–18%), with no significant change over the study period.…”

Section: Discussionmentioning

confidence: 93%

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Resistance to amikacin and gentamicin among Gram-negative bloodstream isolates in a university hospital between 1989 and 1994

Harbarth

Rohner

Safran

et al. 1998

Clinical Microbiology and Infection

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OBJECTIVE: To characterize antimicrobial resistance patterns to amikacin (AN) and gentamicin (GM) among Gram-negative bloodstream isolates and to determine the possible relationship between use of AN and GM and the occurrence of antibiotic resistance during a 6-year period. METHODS: Standard media and techniques of isolation and identification were used. Antimicrobial susceptibility testing was performed with the disk diffusion method and API rapid ATB E strips. Data on consumption of aminoglycosides were collected by the central hospital pharmacy and were expressed as daily defined doses. RESULTS: One thousand nine hundred and four bloodstream isolates were tested for AN and GM susceptibility between 1989 and 1994. Activities of AN and GM remained high during the study period against most isolates of Gram-negative bacteria. No relationship could be observed between the use of AN/GM and the rate of AN/GM resistance. Nosocomial Gram-negative bloodstream isolates showed a higher degree of resistance towards both AN (3.9% of all nosocomial isolates) and GM (7.9%) than community-acquired isolates (1.8% toward AN and 3.1% towards GM, respectively). There was a significant increase (P=0.004) in the risk of GM resistance in patients with nosocomial Gram-negative bacteremia detected more than 14 days after admission. The proportion of GM-susceptible Pseudomonas aeruginosa isolates decreased linearly from 97% for infections acquired between day 3 and day 10 following admission to 80% for bacteremia developing 30 days or more after admission (P=0.008). CONCLUSIONS: AN and GM remain highly active antimicrobial drugs for treatment of GNB in times of growing resistance to cephalosporins and fluoroquinolones.

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Section: Discussionmentioning

confidence: 93%

“…In his study, performed between 1977 and 1985, the yearly GM resistance rate of Gram‐negative bloodstream isolates was 13.2% (range 6–18%), with no significant change over the study period. AN consumption represented less than 11%, so AN resistance was only rarely observed in this study [24].…”

Section: Discussionmentioning

confidence: 95%

Resistance to amikacin and gentamicin among Gram-negative bloodstream isolates in a university hospital between 1989 and 1994

Harbarth

Rohner

Safran

et al. 1998

Clinical Microbiology and Infection

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show abstract

“…Because of the findings noted in Figure 1, specific analysis of NBI was undertaken to determine if the significant increase in rate noted in 1985 to 1987 was NOSOCOMIAL GRAM-NEGATIVE 19791980IQEI 1982196319641985196619871966 1979 1960 1961 1982 1983 1964 1965 1966 1967 There was no significant increase in the quarterly rate of gram-negative NBI (Figure 2A) that would explain the overall increase in NBI from 1985 to 1987. In contrast, evaluation of gram-positive NBI ( Figure 2B) revealed significant increases in rates in 1986 and 1987.…”

Section: Resultsmentioning

confidence: 99%

Nosocomial Bloodstream Infection at a Veterans Hospital; 1979 to 1987

Mylotte¹,

White²,

McDermott³

et al. 1989

Infection Control and Hospital Epidemiology

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Studies of nosocomial bloodstream infection (NBI) have come primarily from university, municipal or community hospitals with little specific information from veterans hospitals. The objective of this study was to define trends in NBI at a tertiary care veterans hospital. Patients with NBI were identified by retrospective review of microbiology records and of infection control surveillance records from 1979 to 1987 at the Buffalo Veterans Administration Medical Center (VAMC). Between 1979 and 1985 there was no significant upward or downward trend. Beginning in early 1986 a significant increase in NBI was noted. This increase was because of changes in incidence of gram-positive NBI (primarily Staphylococcus aureus [corrected] and enterococcus) while there was no change in incidence of gram-negative NBI. The most common source of NBI were similar to previous studies and included urinary tract infection, pneumonia, surgical wound infections and intravenous catheter related infections. The frequency of various organisms causing NBI was likewise similar to other studies except for pneumonia in which Streptococcus pneumoniae most commonly was isolated. The yearly incidence of gentamicin resistance among gram-negative NBI isolates demonstrated no significant trend. In conclusion, there was a significant increase in incidence of NBI at the Buffalo VAMC between 1979 and 1987 that occurred primarily in the last two years studied. The importance of gram-positive organisms as a cause of NBI at the Buffalo VAMC has been clearly documented as a recent phenomenon.

Gentamicin Resistance Among Gram-negative Bacillary Blood Isolates in a Hospital With Long-term Use of Gentamicin

Cited by 7 publications

References 19 publications

Resistance to amikacin and gentamicin among Gram-negative bloodstream isolates in a university hospital between 1989 and 1994

Resistance to amikacin and gentamicin among Gram-negative bloodstream isolates in a university hospital between 1989 and 1994

Nosocomial Bloodstream Infection at a Veterans Hospital; 1979 to 1987

Reports from the literature: Evaluating and monitoring antimicrobial resistance

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