Gentamicin-Resistant Serratia marcescens Endophthalmitis

Ja, Gammon; Schwab, Ivan R.; Joseph, Patrick

doi:10.1001/archopht.1980.01020040073007

Cited by 19 publications

(3 citation statements)

References 23 publications

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“…Hypertensive endophthalmitis has been described secondary to Listeria monocytogenes , including one with concurrent fulminant orbital cellulitis 10 . Nosocomial infections are not uncommon for endogenous endophthalmitis with Serratia marcescens , 11 and have been known to involve extremity dialysis ports 12 like Case 2. Additional reports of endogenous Serratia marcescens endophthalmitis and panophthalmitis may be expected now that arteriovenous fistula placement is recommended as first-line management for dialysis initiation and has approximately doubled in the past decade in the United States 13 .…”

Section: Discussionmentioning

confidence: 99%

Endogenous Serratia marcescens panophthalmitis: A case series

Breazzano

Jonna

Nathan

et al. 2019

American Journal of Ophthalmology Case Reports

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Purpose – Two rare and unusual cases of endogenous panophthalmitis from Serratia marcescens are presented with mechanisms for infection explored. Observations – The first patient had history of intravenous drug use (IVDU) without any medical implants. The second patient, in addition to IVDU, had a history of end-stage renal disease with upper extremity arteriovenous fistula graft infection from Serratia marcescens confirmed by wound culture. One patient had a history of licking the needles prior to IV drug injection. Clinical exam in both cases revealed light perception vision, relative afferent pupillary defect, periorbital edema with limited extraocular motility, and hypopyon in the affected eyes. Cultures from the anterior chamber aspirate were positive for Serratia marcescens in the first case and demonstrated Gram-negative rods in the second. Attempted vitreous aspiration was unsuccessful at obtaining specimens. Computed tomography demonstrated orbital fat stranding without abscess, and histopathology showed intense neutrophilic infiltration in all layers of enucleated specimen in case one. Conclusions and Importance Needle licking may be an underappreciated mechanism for endogenous endophthalmitis in intravenous drug users. This report includes the first case in the literature, to authors’ knowledge, of non-nosocomial endogenous Serratia marcescens panophthalmitis with orbital cellulitis. The second case illustrates a rare consequence of the rise in arteriovenous fistula placement and dialysis across the United States, which may predispose to future cases of endogenous Serratia marcescens endophthalmitis. This series supports previous observations of Serratia marcescens endogenous endophthalmitis exhibiting a generally poor visual prognosis.

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Section: Discussionmentioning

confidence: 99%

Endogenous Serratia marcescens panophthalmitis: A case series

Breazzano

Jonna

Nathan

et al. 2019

American Journal of Ophthalmology Case Reports

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“…Die Haufigkeit ist jedoch sicher höher, da viele Patienten mit dieser Erkrankung aufgrund der Begleiterkrankungen oft nicht augenarztlich untersucht werden. Die meisten publizierten Kasuistiken sind klinisch Kim Monatsbl Augenheilkd 1999 214: 44-49 1999 F. Enke Verlag Stuttgart orientiert (19,4,7,10,14,19),und es finden sich nurwenige Publikationen mit histologischen Befunden aus der Akutphase der metastatisch bakteriellen Endophthalmitis (1,3,6,13,20). Wir berichten einen Patient, der im Endstadium einer aplastischen Anämie die Zeichen einer metastatischen Endophthalmitis zeigte.…”

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Okuläre Bakteriose bei einem Patienten mit aplastischer Anämie

Spraul¹,

Roth²,

Möller³

et al. 1999

Klin Monatsbl Augenheilkd

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The histologic results in our patient displayed numerous bacilli without inflammatory reaction which was a result of the aplastic state. Therefore, this disease was classified as "ocular bacteriosis". The blood-ocular barrier undergoes direct assault with intraocular inflammation and the impermeability to blood-borne antibiotics is lost. However, with the lack of an inflammatory reaction the permeability to antibiotics may be too low and the achieved concentration insufficient.

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“…This bacterium can cause meningitis, endocarditis, otitis media, sepsis, and ocular infections such as conjunctivitis and keratitis. [1][2][3] Endogenous bacterial endophthalmitis is uncommon but its occurrence in newborns has been reported. 2 We report a newborn infant who developed a pink hypopyon caused by Serratia marcescens.…”

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confidence: 99%

Pink hypopyon: a sign of Serratia marcescens endophthalmitis.

Hazzaa

Tabbara

Gammon

1992

British Journal of Ophthalmology

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Endogenous bacterial endophthalmitis in infants is uncommon. We recently examined and treated an infant who presented with pink hypopyon which followed a Serratia marcescens septicaemia. Culture ofthe aspirate from the anterior chamber showed no red blood cells, and grew Serratia marcescens, which was also isolated from the tip of the child's umbilical artery catheter. The presence of a pink hypopyon in the absence ofhyphaema may suggest the diagnosis of Serratia marcescens endophthalmitis. (BrJ Ophthalmol 1992; 76: Case report After an uneventful pregnancy, a healthy 18-year-old primigravida had an uncomplicated labour and delivered a 2-65 kg full term infant. The neonate required resuscitation after delivery. Apgar scores were 1 at 5 minutes, 3 at 6 minutes, and 5 at 10 minutes. During the first few hours of life, the baby developed convulsions and was treated with 60% oxygen and phenobarbitone. Three days later the infant developed clinical signs of septicaemia and disseminated intravascular coagulopathy. Serratia marcescens was isolated from blood cultures and from the infant's ear, nose, and throat. S marcescens was also cultured from the tip of the child's umbilical artery catheter.Ophthalmic examination disclosed a normal right eye. The left cornea was hazy centrally. A fibrinous exudate was seen in the anterior chamber occluding the pupil and precluding visualisation of the fundus. A pink hypopyon occupied one third of the anterior chamber.

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Gentamicin-Resistant Serratia marcescens Endophthalmitis

Cited by 19 publications

References 23 publications

Endogenous Serratia marcescens panophthalmitis: A case series

Endogenous Serratia marcescens panophthalmitis: A case series

Okuläre Bakteriose bei einem Patienten mit aplastischer Anämie

Pink hypopyon: a sign of Serratia marcescens endophthalmitis.

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