Gentamicin sulfate distribution in body fluids

Rodriguez, Victorio; Stewart, Oorothy; Bodey, Gerald P.

doi:10.1002/cpt1970112275

Cited by 31 publications

(7 citation statements)

References 4 publications

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“…The mean serum concentration per day for gentamicin varied from 3.9 i 0.6 to 5.6 i 0. 8 ,gg/ml (Table 1). There was no evidence for cumulation of drug with increasing duration of therapy.…”

Section: Methodsmentioning

confidence: 99%

“…Patient 1-A developed a BUN of 26 mg/100 ml and creatinine of 1.4 mg/100 ml after 11 days VOL. 8,1975 therapy. Three days later his BUN increased to 38 mg/100 ml, but within the next 4 days it decreased to 20 mg/100 ml with a creatinine of 1.0 mg/100 ml.…”

Section: Methodsmentioning

confidence: 99%

“…However, their efficacy is diminished in neutropenic patients (1). Customary practice has been to administer these drugs by an interrupted dosage schedule at 6-to 8-h intervals, which results in high peak serum concentrations (8,10). However, the serum concentrations 6 to 8 h after a dose of gentamicin sulfate, sisomicin, or tobramycin is usually less than 1.0 gg/ml, which is below the minimum inhibitory concentration (MIC) of these antibiotics against many gram-negative bacilli (3,(6)(7)(8)10).…”

mentioning

confidence: 99%

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Feasibility of Administering Aminoglycoside Antibiotics by Continuous Intravenous Infusion

Bodey

Chang

Rodriguez

et al. 1975

Antimicrob Agents Chemother

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Eleven patients each received gentamicin sulfate, tobramycin, and sisomicin by continuous intravenous infusion after an initial loading dose. Subsequent doses of antibiotic were adjusted in an attempt to maintain constant serum concentrations. There was considerable variation in the serum concentration from patient to patient and in the same patient from day to day with each drug. Although the dosages of gentamicin sulfate and tobramycin were similar, the serum concentrations of the latter drug were consistently lower. Despite the daily administration of doses of at least 300 mg of gentamicin and tobramycin per m2 and 160 mg of sisomicin per m2, nephrotoxicity occurred in only three patients. This is a low frequency of nephrotoxicity, considering the dosages of drug administered. Although therapeutic efficacy was not an objective of this study, 8 of 11 documented infections were cured. This approach to the administration of aminoglycoside antibiotics deserves therapeutic trials.

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“…The mean serum concentration per day for gentamicin varied from 3.9 i 0.6 to 5.6 i 0. 8 ,gg/ml (Table 1). There was no evidence for cumulation of drug with increasing duration of therapy.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Feasibility of Administering Aminoglycoside Antibiotics by Continuous Intravenous Infusion

Bodey

Chang

Rodriguez

et al. 1975

Antimicrob Agents Chemother

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“…Plasma protein binding is low, highly soluble in water, with distribution resembling extracellular fluid compartments [134,135]. Appropriate concentrations are attained in all body fluids except for CSF and vitreous humor [136][137][138]. They undergo renal clearance unchanged with minimal excretion via feces [139].…”

Section: Pharmacokineticsmentioning

confidence: 99%

Bactericidal and Bacteriostatic Antibiotics

Patil¹,

Patel²

2021

Infections and Sepsis Development

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Of all the medications available to physicians worldwide, antibiotics play an essential role in inpatient and outpatient settings. Discovered in the early nineteenth century by Alexander Fleming, penicillin was the first antibiotic isolated from a mold. Dr. Gerhard Domagk developed synthetic sulfa drugs by altering the red dye used in chemical industries. Since then, multiple antibiotic classes have been discovered with varying antimicrobial effects enabling their use empirically or in specific clinical scenarios. Antibiotics with different mechanisms of action could be either bactericidal or bacteriostatic. However, no clinical significance has been observed between cidal and static antibiotics in multiple trials. Their presence has led to safer deep invasive surgeries, advanced chemotherapy in cancer, and organ transplantation. Indiscriminate usage of antibiotics has resulted in severe hospital-acquired infections, including nosocomial pneumonia, Clostridioides difficile infection, multidrug-resistant invasive bacterial infections, allergic reactions, and other significant side effects. Antibiotic stewardship is an essential process in the modern era to advocate judicial use of antibiotics for an appropriate duration. They play a vital role in medical and surgical intensive care units to address the various complications seen in these patients. Antibiotics are crucial in severe acute infections to improve overall mortality and morbidity.

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“…'Ελάχιστα διέρχεται τόν φραγμόν α'ίματος-έγκεφάλου ακόμη καί επί φλεγμονής των (Rodriguez et al 1970, Rahal 1972. Συνεπώς κατά τήν διάρ κεια της θεραπείας τό φάρμακον πρέπει νά χορηγήται καί ένδορραχιαίως εις δόσιν 5 mg/ΐδωρον περίπου.…”

Section: αμινογλυκοσιδαιunclassified

Φαρμακοκινητικη Μελετη Της Κεφσουλοντινης

Κουμαδιτησ¹

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Gentamicin sulfate distribution in body fluids

Cited by 31 publications

References 4 publications

Feasibility of Administering Aminoglycoside Antibiotics by Continuous Intravenous Infusion

Feasibility of Administering Aminoglycoside Antibiotics by Continuous Intravenous Infusion

Bactericidal and Bacteriostatic Antibiotics

Φαρμακοκινητικη Μελετη Της Κεφσουλοντινης

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