Gentamicin sulphate release from lost foam wollastonite scaffolds using poly(dl-lactide-co-glycolide) acid

Barrera‐Méndez, Felipe; Escobedo‐Bocardo, José C.; Cortés-Hernández, Dora A.; Almanza-Robles, J.M.; Múzquiz-Ramos, E.M.

doi:10.1016/j.ceramint.2011.03.035

Cited by 11 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…hours [201,279,280], and 1 to 10 C/min [278,281], respectively. Indeed the sintering parameters will depend on the processing stages proceeding the sintering stage, such as the purity of the raw powder, and size of article to be sintered.…”

Section: Achieving Permanence Of the Hydroxyapatite Scaffoldmentioning

confidence: 95%

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

View full text Add to dashboard Cite

show abstract

Section: Achieving Permanence Of the Hydroxyapatite Scaffoldmentioning

confidence: 95%

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

View full text Add to dashboard Cite

show abstract

“…Nevertheless, it has been shown that the modification of halloysite with inorganic compounds can also be effective and increase the loading capacity, as noted in the case of ibuprofen incorporated into halloysite modified with APTES ((3-aminopropyl) triethoxysilane) and silane. Such a modification had a very positive effect on the release kinetics of this active substance, and its release time was 2.5 times longer and amounted to 50 h compared to unmodified halloysite, whose release time was only 20 h [ 34 , 35 ]. Other studies have shown that halloysite bi-functionalized with two ligands—folic acid and fluorochrome—and doped with the anti-cancer drug methotrexate, showed a high efficiency in drug loading and a prolonged release time [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Halloysite Nanotubes as Potential Drug Carriers

Stodolak-Zych

Rapacz-Kmita

Gajek

et al. 2023

JFB

View full text Add to dashboard Cite

The aim of the work was to examine the possibility of using modified halloysite nanotubes as a gentamicin carrier and to determine the usefulness of the modification in terms of the effect on the amount of the drug attached, its release time, but also on the biocidal properties of the carriers. In order to fully examine the halloysite in terms of the possibility of gentamicin incorporating, a number of modifications of the native halloysite were carried out prior to gentamicin intercalation with the use of sodium alkali, sulfuric and phosphoric acids, curcumin and the process of delamination of nanotubes (expanded halloysite) with ammonium persulfate in sulfuric acid. Gentamicin was added to unmodified and modified halloysite in an amount corresponding to the cation exchange capacity of pure halloysite from the Polish Dunino deposit, which was the reference sample for all modified carriers. The obtained materials were tested to determine the effect of surface modification and their interaction with the introduced antibiotic on the biological activity of the carrier, kinetics of drug release, as well as on the antibacterial activity against Escherichia coli Gram-negative bacteria (reference strain). For all materials, structural changes were examined using infrared spectroscopy (FTIR) and X-ray diffraction (XRD); thermal differential scanning calorimetry with thermogravimetric analysis (DSC/TG) was performed as well. The samples were also observed for morphological changes after modification and drug activation by transmission electron microscopy (TEM). The conducted tests clearly show that all samples of halloysite intercalated with gentamicin showed high antibacterial activity, with the highest antibacterial activity for the sample modified with sodium hydroxide and intercalated with the drug. It was found that the type of halloysite surface modification has a significant effect on the amount of gentamicin intercalated and then released into the surrounding environment but does not significantly affect its ability to further influence drug release over time. The highest amount of drug released among all intercalated samples was recorded for halloysite modified with ammonium persulfate (real loading efficiency above 11%), for which high antibacterial activity was found after surface modification, before drug intercalation. It is also worth noting that intrinsic antibacterial activity was found for non-drug-intercalated materials after surface functionalization with phosphoric acid (V) and ammonium persulfate in the presence of sulfuric acid (V).

show abstract

“…To prevent bone infection after an implantation operation, generally an antibiotic such as gentamicin, which has a broad spectrum of activity against both Gram‐positive and Gram‐negative bacteria, is used . In the literature, there are articles explaining the addition of antibiotics either in the scaffolds during preparation or on the scaffold by adsorption . However, the addition of bioactive agents in microspheres or nanospheres and then the combination with the scaffold material is a more novel technique.…”

Section: Introductionmentioning

confidence: 99%

Poly(ε‐caprolactone) composite scaffolds loaded with gentamicin‐containing β‐tricalcium phosphate/gelatin microspheres for bone tissue engineering applications

Sezer

Arslantunali

Aksoy

et al. 2013

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this study, novel poly(ε‐caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin‐loaded β‐tricalcium phosphate (β‐TCP)/gelatin microspheres were added to PCL. The effects of the amount of β‐TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos‐2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110.

show abstract

Gentamicin sulphate release from lost foam wollastonite scaffolds using poly(dl-lactide-co-glycolide) acid

Cited by 11 publications

References 18 publications

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Functionalized Halloysite Nanotubes as Potential Drug Carriers

Poly(ε‐caprolactone) composite scaffolds loaded with gentamicin‐containing β‐tricalcium phosphate/gelatin microspheres for bone tissue engineering applications

Contact Info

Product

Resources

About