Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility

Liu, Yangyang; Bai, Yang; Pan, Yue; Xu, Zhifang; Fang, Yuxin; Wang, Shenjun; Yuanhao, Du; Guo, Yi

doi:10.1155/2019/9043151

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Currently, in addition to following the principles of Deqi and consciousness‐restoring resuscitation ( Xingnao Kaiqiao ), clinicians and researchers have gradually paid attention to the quantification and standardization of acupuncture stimulation parameters. Manual acupuncture (MA) is the traditional acupuncture technique, which implies treating patients by inserting thin, solid needles into acupoints on the skin (Liu et al, 2019). On the basis of MA, in the past few decades, researchers have combined traditional acupuncture techniques with modern physical techniques such as electrical, thermal, optical, acoustic, and magnetic, and subsequently developed a variety of new acupuncture techniques or auxiliary devices (Ku et al, 2018) for the treatment of brain diseases.…”

Section: Explorationmentioning

confidence: 99%

Acupuncture for brain diseases: Conception, application, and exploration

Gao

Wang

Meng

et al. 2022

The Anatomical Record

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The brain is probably the most complex organ in the human body. It has been the hot spot and direction of brain science research all over the world to deeply study the pathogenesis of various kinds of brain diseases and find effective treatment methods. Acupuncture is a nonpharmacological therapy of traditional Chinese medicine originating from ancient clinical practice. The research on the treatment of brain diseases by acupuncture has been constantly enriched and updated with the promotion of interdisciplinary research. In order to account for the current achievements in the field of acupuncture for brain diseases, this article reviews it in terms of conception, application, and exploration. Based on the literature review, we found that in the past decades, acupuncture has received widespread attention worldwide and many literatures have reported the clinical efficacy and underlying mechanisms of acupuncture in the treatment of brain diseases. Presently, the conception, application, and exploration of acupuncture in the treatment of brain diseases have evolved from empirical medicine to evidence‐based medicine and precision medicine, and are experiencing a deeper understanding of the information about acupuncture regulating the brain function based on interdisciplinary research.

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Section: Explorationmentioning

confidence: 99%

Acupuncture for brain diseases: Conception, application, and exploration

Gao

Wang

Meng

et al. 2022

The Anatomical Record

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“…MA is wildly used in clinical practice, which involves inserting a disposable, sterile needle to the acupuncture point (acupoint), and manipulating the needle with manual operations, such as lifting-thrusting and twirling-rotating needle in order to elicit Deqi sensation and to produce a therapeutic effect. Variations in the frequency, forcefulness, amplitude, and duration of the operations may produce a different stimulation intensity that affects the effectiveness of acupuncture treatment [9][10][11][12][13]. However, the intensity-effect relationship of MA and its mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Strong Twirling-Rotating Manual Acupuncture with 4 r/s Is Superior to 2 r/s in Relieving Pain by Activating C-Fibers in Rat Models of CFA-Induced Pain

Song

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Manual acupuncture (MA) with different stimulus frequencies may give rise to varying acupuncture effects. However, the intensity-effect relationship and the underlying mechanisms of MA remain unclear. Objective. To compare the analgesic effects of different frequencies of twirling-rotating MA on rats with complete Freund’s adjuvant- (CFA-) induced pain and explore the underlying mechanism via peripheral sensory nerves. Methods. First, 36 healthy male Wistar rats were randomly divided into 6 groups: control group, 2 r/s MA group (twirling-rotating MA with the frequency of 2 revolutions per second), 4 r/s MA group (twirling-rotating MA with the frequency of 4 revolutions per second), CFA group, CFA + 2 r/s MA group, and CFA + 4 r/s MA group. Rats in three CFA groups received an intraplantar injection of CFA to establish a pain model, while the rats in other three groups received an intraplantar injection of saline. Rats in the 2 r/s MA group and 4 r/s MA group were treated with the corresponding frequencies of twirling-rotating MA on bilateral Zusanli (ST36) and Kunlun (BL60) for 7 days. The ipsilateral nociceptive thresholds (paw withdrawal latency; PWL) were tested to evaluate the analgesic effects. Second, 9 healthy male Wistar rats were randomly divided into 3 groups: control group, 2 r/s MA group, and 4 r/s MA group. The proportion of C-fiber neurons (calcitonin gene-related peptide- (CGRP-) positive neurons) and A-fiber neurons (neurofilament 200- (NF200-) positive neurons) in the dorsal root ganglia (DRG) activated by MA were quantitatively analyzed with the morphological immunofluorescence staining method. Third, 30 healthy male Wistar rats were randomly divided into 6 groups: control group, CFA group, CFA + 2 r/s MA group, CFA + 2 r/s MA + RTX group, CFA + 4 r/s MA group, and CFA + 4 r/s MA + RTX group. Resiniferatoxin (RTX) was injected into the acupoints before acupuncture. PWL was evaluated to investigate the analgesic effect. Results. Both types of MA treatment increased the PWL of saline-injecting rats and pain model rats. Moreover, 4 r/s MA was superior to 2 r/s MA in increasing PWL. A higher quantity of excited C-fiber neurons was observed following 4 r/s MA than 2 r/s MA, while the reverse was observed in the activation of A-fiber neurons. Following the injection of RTX to inhibit the activation of C-fibers, the analgesic effect of 4 r/s MA reduced significantly but not of 2 r/s MA. Conclusion. Strong MA (4 r/s MA) has superior analgesic effects to gentle MA (2 r/s MA) on CFA model rats, which is associated with C-fiber activation.

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