Genus Erythrophleum: Botanical description, traditional use, phytochemistry and pharmacology

Son, Ninh The

doi:10.1007/s11101-019-09640-0

Cited by 24 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparing them, the minimal calculated result is desired, and the representative mechanism takes place easier. [29][30][31][32][33], there have not been extensively DFT calculated approaches to report interactions between RSV and DPPH radicals, to date. In this paper, the kinetics between them in water is the first aim since RSV was typical compounds having good solubility in water [34].…”

Section: Preferential Mechanismsmentioning

confidence: 99%

Antioxidant of Trans-Resveratrol: A Comparison between OH and CH Groups Based on Thermodynamic Views

Thi

2020

Journal of Chemistry

View full text Add to dashboard Cite

Trans-resveratrol establishes the planarity in its structure which makes it an interesting compound in both experimental and theoretical examinations. The current study, using the density functional method (DFT), attempts to compare the antioxidative capacities between hydroxyl (OH) and aromatic methine (CH) groups of this molecule. Becke’s exchange-correlation B3LYP functional together with 6-311++G(d, p) basis set was used to reveal the effects of structural geometry and electronic feature on the antioxidative results of OH and CH groups. The antioxidative action of trans-resveratrol has followed the HAT mechanism in gas, but the SPLET pathway in liquids. OH bond breaking is easier than CH bond disruption. 4-OH bond breaking induces the lowest BDE values of 74.4–77.9 kcal/mol in gas, acetone, methanol, and water, as well as the lowest PA values of 37.2–46.2 kcal/mol in acetone, methanol, and water. From the kinetic view, 4-OH is also an active center to capture laboratory radical DPPH, ROS radicals HOO• and CH3O•, and RNS radical •NO2.

show abstract

Section: Preferential Mechanismsmentioning

confidence: 99%

Antioxidant of Trans-Resveratrol: A Comparison between OH and CH Groups Based on Thermodynamic Views

Thi

2020

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…The use of plants by human populations has an important chemical aspect, which can mediate complex people–plant relationships [ 42 ]. The perennial plants of Erythrophleum genus are being threatened by over-exploitation due to their critical roles in the medicinal applications (in particular for E. fordii and E. lasianthum ), especially for their high content of cardiac alkaloids [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Erythrophleum species have a particular metabolome composed a priori of large amounts of molecules with the specific cassane-type diterpene scaffold [ 17 , 18 , 19 ]. These are specific scaffolds long recognized for cardiac effects in humans [ 20 ]. Cassane-type diterpenes usually named as “cassaine alkaloids” or “ Erythrophleum alkaloids” were long known as the main specialized metabolites found in the Erythrophleum genus [ 21 ] whereas the distribution of nor -cassane diterpenes is restricted to Caesalpinia [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

et al. 2021

View full text Add to dashboard Cite

Secondary metabolites are essential for plant survival and reproduction. Wild undomesticated and tropical plants are expected to harbor highly diverse metabolomes. We investigated the metabolomic diversity of two morphologically similar trees of tropical Africa, Erythrophleum suaveolens and E. ivorense, known for particular secondary metabolites named the cassaine-type diterpenoids. To assess how the metabolome varies between and within species, we sampled leaves from individuals of different geographic origins but grown from seeds in a common garden in Cameroon. Metabolites were analyzed using reversed phase LC-HRMS(/MS). Data were interpreted by untargeted metabolomics and molecular networks based on MS/MS data. Multivariate analyses enabled us to cluster samples based on species but also on geographic origins. We identified the structures of 28 cassaine-type diterpenoids among which 19 were new, 10 were largely specific to E. ivorense and five to E. suaveolens. Our results showed that the metabolome allows an unequivocal distinction of morphologically-close species, suggesting the potential of metabolite fingerprinting for these species. Plant geographic origin had a significant influence on relative concentrations of metabolites with variations up to eight (suaveolens) and 30 times (ivorense) between origins of the same species. This shows that the metabolome is strongly influenced by the geographical origin of plants (i.e., genetic factors).

show abstract

“…Phytochemical and pharmacological studies of medicinal plants have made substantial progress in recent years, with an emphasis on novel molecules with therapeutic qualities. 11–17 The focus of this section is on publications over the last 40 years that deal with phytochemical investigations of Tupistra species. Up to now, approximately 200 compounds with diverse chemical structures have been isolated from the Tupistra genus, but steroid derivatives have predominated.…”

Section: Phytochemistrymentioning

confidence: 99%

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Linh

Son

2022

Natural Product Communications

Self Cite

View full text Add to dashboard Cite

In the current paper, secondary metabolites separated from Tupistra plants have been reviewed. Approximately 200 phytochemicals, classified in various chemical classes of bioactive compounds, have been compiled, along with their sources and references. The most striking feature is that the most frequently isolated compounds have been spirostanol sapogenins, and spirostanol and furostanol saponins, most of which are new in nature. The application of both Tupistra plant extracts and isolated compounds in biological assays is also one of the crucial aims in pharmacological discoveries. Tupistra constituents have demonstrated valuable properties in the field of pharmacology, such as antioxidative, antimicrobial, antidiabetic, and antihepatic activities, but their cytotoxic and anti-inflammatory actions can be considered as the more remarkable. In vivo cancer-related activities of the tested Tupistra samples were mostly based on apoptosis. Further phytochemical investigations, together with extensive assessments of the biological profiles and mechanism of action studies of the components of Tupistra species are to be expected.

show abstract

Genus Erythrophleum: Botanical description, traditional use, phytochemistry and pharmacology

Cited by 24 publications

References 49 publications

Antioxidant of Trans-Resveratrol: A Comparison between OH and CH Groups Based on Thermodynamic Views

Antioxidant of Trans-Resveratrol: A Comparison between OH and CH Groups Based on Thermodynamic Views

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Contact Info

Product

Resources

About