Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Abstract

Ethnopharmacological relevance: The genus Mallotus (Euphorbiaceae family) includes 124 accepted names and distributes in tropical and sub-tropical regions. Some Mallotus species are used in traditional medicines for the treatment of chronic hepatitis, enteritis stomach, disorders, cholelithiasis, anti-cancer, gastric, and duodenal ulcers.
 Aim of the study: According to the Scifinder database, this is the first review study that focuses on the phytochemistry and pharmacology of Mallotus genus (17 Mallotus species) to understand the link between the traditional medicinal uses, phytochemistry, and bioactivities. Thus, they provides a scientific fundamental for further research in the phytochemical and pharmacological activities of their species.
 Materials and methods: Information about the Mallotus genus was collected using various databases, such as Web of Science, SciFinder, PubMed, Sci-hub, Google Scholar, Wiley, Elsevier, ACS publications, and SpringerLink between 1978 and 2021. Plant names were validated by “The Plant List” (www.theplantlist.org).
 Results: Up to now, total 325 compounds were reported from Mallotus species, including phloroglucinols, steroids, coumarins, benzopyrans, flavonoids, chalcones, galics, and bergenins. The extracts and phytochemical constituents of the Mallotus genus are a rich source of biologically active, including anti-cancer, anti-inflammatory, immunoregulatory, antioxidant, antibacterial, antifungal, anti-virus, and other activities.
 Conclusions: The review indicated that the Mallotus genus is a promising source of biological activities compounds, special anti-cancer chromanes. The results of this review confirm the great potential of Mallotus species. Thus, it will be helpful for further research in the phytochemistry and pharmacology of the Mallotus genus.

Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects

“…Taken together, our results show that the zebrafish embryotoxicity test reveals potential toxic or developmental effects caused by extracts from traditional medicinal plants ( Table 4 ). The traditional use of the different medicinal plants investigated here range from anti-inflammatory, stomachache, and duodenum ulcers (KT14), anti-tumor (KT09, KT11, KT14, KT20), antioxidant, antimicrobial to antiviral [ 72 , 80 , 81 ]. A literature review of their chemical composition revealed compounds of particular interest, such as quercetin, ursolic acid, berberine and palmatine [ 72 , 82 , 83 ].…”

Methanolic Extract of Mallotus roxburghianus Muell. Exhibit Anti-Cancer Activity against Dalton’s Lymphoma Ascites (DLA) bearing Mice via Alterations of Apoptotic Genes E xpression and Redox-Homeostasis

“…Compounds isolated from M. oppositifolius showed potent antioxidant, antibacterial and antimalarial activities. The root extract of M. apelta and compounds isolated from M. japonicus showed significant antiviral activity (2) . M. roxburghianus has been reported to contain phenols, alkaloids, saponins, terpenes, tannins, triterpenoids, steroids, reducing sugars, coumarin, berginin, gallic acid, gentisic acid, gums, and a variety of other natural substances, particularly flavonoids like chrysin, hesperidin, naringenin, quercetin, and rutin.…”