Genus Opuntia: A Golden Source of Compounds with Anti-Inflammatory Potential

Youssef, Fadia S.

doi:10.1007/978-3-030-78444-7_19

Cited by 1 publication

(1 citation statement)

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“…The Cactaceae family includes several species, many of which are endemic to Mexico [ 1 ]. The knowledge and use of these cacti date from the pre-Hispanic era, with records of their use as food, construction material, fences, soil fixers that prevent erosion, and fodder [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Bioactivities of Cactaceae Family Members Endemic to Mexico

Rodríguez-Mendoza

Campos

Lorenzo-Leal

et al. 2022

Plants

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Mexico is a center of diversification for the Cactaceae family, with 69% of the species recorded as endemic. Certain members of the Cactaceae family have been chemically analyzed to relate their medicinal use with their phytochemistry. Here, the phytochemistry and bioactivity of ethanol extracts of Ferocactus echidne, F. latispinus, and Mammillaria geminispina were evaluated. A preliminary phytochemical analysis was performed, detecting the presence of saponins, tannins, cardiotonic glycosides, and sesquiterpene lactones. The presence of nicotinic acid in F. echidne and F. latispinus was identified by GC-MS. Other compounds found in the extracts of these three species were gentisic acid, diosmetin, chlorogenic acid, N-methyltyramide, and hordenine. The antioxidant activity was estimated with the DPPH free radical scavenging test. To determine the toxicity of the extracts, the in vivo model of Artemia spp. was used. In addition, the cytotoxicity of the extract was tested on C6, HaCaT, THP-1, and U937 cell lines, while the inflammatory activity was tested by measuring the secretion of cytokines using macrophage cells. The three species showed different bioactivities, including antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities. To the best of our knowledge, the results presented here are the first described for these species.

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Section: Introductionmentioning

confidence: 99%