Genus Salacia: Chemical Composition, Antidiabetic Effect and other Bioactivities

Laikowski, Manuela M.; Souza, Debora M. de; Moura, Sidnei

doi:10.2174/2210315505666150930225628

Cited by 2 publications

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“…About 200 compounds have been isolated and identified from this genus. [1] Terpenoid and phenolic compounds are the major components. There are many bioactive compounds such as mangiferin and a series of thiosugar sulfonium sulfates (salacinol, salaprinol, kotalanol, neokotalanol, ponkoranol), have been isolated from this genus.…”

Section: Introductionmentioning

confidence: 99%

“…In a continued study on the screening of medicinal plants for α-glucosidase inhibitory activity, [4,5] it was found that a methanolic extract of the stems of S. chinensis showed strong αglucosidase inhibitory activity, with an IC50 value of 0.3 g mL -1 . Thus, an activity-guided fractionation was carried out, leading to the isolation of six compounds (1)(2)(3)(4)(5)(6), and their α-glucosidase inhibitory activities were evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α‐glucosidase inhibitory activities

Truc

Dang

et al. 2019

Vietnam Journal of Chemistry

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Six lupan-type triterpenoids: 29-norlupan-3,20-dione (1), 3β-hydroxy-29-norlupan-20-one (2), betulonic acid (3), salacianol (4), 30-hydroxylup-20(29)-en-3-one (5), and lup-20(29)-ene-3β,30-diol (6) have been isolated from the CHCl3-soluble fraction of the stem of Salacia chinensis L. (Celastraceae). Their chemical structures were elucidated based on the NMR spectroscopic analysis and comparison with the literatures. Compounds (5) and (6) showed very weak α-glucosidase inhibitory activity with the IC50 values of 211.5 and 246.8 M, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α‐glucosidase inhibitory activities

Truc

Dang

et al. 2019

Vietnam Journal of Chemistry

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Isolation and Simultaneous Quantiﬁcation of Nine Triterpenoids fromRosa davuricaPall.

Huo

Gao

et al. 2016

J Chromatogr Sci

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Rosa davurica Pall. has been used as a traditional Oroqen medicine to treat dyspepsia, gastroenterologia, menoxenia and other diseases. In this study, the chemical constituents research on the fruit pulp of R. davurica led to the isolation and identification of nine bioactive pentacyclic triterpenoids and five of them were isolated from the plant for the first time. Subsequently a simple and rapid high-performance liquid chromatography (HPLC) method was established for the simultaneous quantification of the nine triterpenoids. The separation was performed on a Merges reverse phase (RP) C (250 × 4.6 mm, 5 μm) column through 40 min gradient delivery of 0.05% phosphoric acid aqueous solution and acetonitrile at a flow rate of 1.2 mL/min at 30°C and the detection wavelength selected was 210 nm. All of the calibration curves showed good linearity (R > 0.9990) in the tested ranges. The limit of detection and the limit of quantitation were in the range of 0.21-1.27 μg/mL and 0.63-3.80 μg/mL, respectively. The established method also showed good precision, repeatability and recovery and can be used to the routine quality control of R. davurica and other herbs containing pentacyclic triterpenoids.

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Genus Salacia: Chemical Composition, Antidiabetic Effect and other Bioactivities

Cited by 2 publications

References 0 publications

Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α‐glucosidase inhibitory activities

Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α‐glucosidase inhibitory activities

Isolation and Simultaneous Quantiﬁcation of Nine Triterpenoids fromRosa davuricaPall.

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