This paper presents new data on the spatial organization of mound-builder groups in the India Muerta wetlands, Uruguay. This area presents the beginning of land architecture in the region (ca. 4800–5000 years BP), associated with more arid climate. This construction tradition continues and intensifies, mainly from ca 3000 years BP, from the establishment of warmer and damper conditions. New sources of information and geospatial technologies have made it possible to locate mound sites with greater precision, as well as to analyze settlement patterns. Indigenous communities occupied areas of hills, plains and wetlands, showing differences but also regularities in spatial organization in each area. In the whole area, earthen mound complexes form groups of different orders, from regional to domestic units, configured by mounds, negative structures and limited spaces. The location of the mounds is primarily in dry areas, known locally as islands, which are prominent in the landscape during floods in this wetland-dominated environment. Through this analysis of the landscape, this work delves into the underlying logic of the social construction of the territory. The results achieved in this paper are consistent with previous research suggesting planned occupation associated with villages integrated within broader regional systems.