The Principal Cordillera of Central Chile is characterized by two belts of different ages and lithologies: (i) an eastern Mesozoic belt, consisting of limestone-and gypsum-rich sedimentary rocks at the border between Central Chile and Argentina, where the active volcanic arc occurs; and (ii) a western belt of Cenozoic age containing basaltic to andesitic volcanic and volcanoclastic sequences. This distinctive geological setting controls water chemistry of cold and thermal springs in the region, which are fed by meteoric water that circulates through deep regional structures. In the western sector of Principal Cordillera, water-rock interaction processes produce low TDS, slightly alkaline HCO 3 − dominated waters, although dissolution of underlying Mesozoic evaporitic rocks occasionally causes SO 4 2− and Cl − enrichments. In this area, few Na dolomite, anhydrite, fluorite, albite, K-feldspar and Ca-and Mg-saponites at a broad range of temperatures (up tõ 300°C) In the associated gas phase, equilibria of chemical reactions characterized by slow kinetics (e.g. sabatier reaction) suggested significant contributions from hot and oxidizing magmatic gases. This hypothesis is consistent with the δ 13 C-CO 2 , Rc/Ra, CO 2 / 3 He values of the fumarolic gases. Accordingly, the isotopic signatures of the fumarolic steam is similar to that of fluids discharged from the summit craters of the two active volcanoes in the study area (Tupungatito and Planchón-Peteroa). These results encourage the development of further geochemical and geophysical surveys aimed to provide an exhaustive evaluation of the geothermal potential of these volcanic-hydrothermal systems.