The tank cascade system (TCS) has been used for over 2000 years for water management in Sri Lanka. Since surface water is limited in the dry zone of Sri Lanka, agricultural production, especially of upland crops, relies on groundwater for irrigation. We sampled 29 wells in the Ulagalla cascade, a prominent TCS near Anuradhapura city in the dry zone of Sri Lanka, in Yala (dry) and Maha (wet) seasons, the two main cropping seasons in Sri Lanka. We evaluated the suitability of groundwater for irrigation using the analytic hierarchy process and geographical information system. Water quality did not vary notably between seasons. However, it deteriorated with the onset of high intensity heavy rain, especially during the Maha season. A water quality zoning map indicated that groundwater in 4% and 96% of the study area is suitable and moderately suitable for irrigation, respectively. Irrigation water quality in tank cascade landscapes and similar environments can be assessed using this methodology and our results.