In Indonesia, small-scale rock mining is generally managed by traditional miners. For example, the andesite rock mining in Bulu Alakkuang has been exploited for approximately one hundred years. Mining waste is channeled directly into the Panreng River, located on the north side of the mining area. Rock mining waste contains sediment particles where the sediment plays an urgent role in the movement and accumulation of heavy metals that could lead to the cause of toxic effects on biota. The particular study aimed to analyze the levels and distribution of heavy metals Cu and Zn in the sediments of the Panreng River, Sidenreng Rappang Regency, South Sulawesi Province. The geochemical method was an Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) analysis of 24 sediment samples taken systematically along the Panreng River. Then, data from the analysis of ICP-AES geochemical was analyzed for the Enrichment Factor (EF) and Geoaccumulation Index (Igeo). The metal of Cu tends to be high in the downstream area, while the metal of Zn tends to have an average value at all stations. The calculation result of EF showed the Cu content was in a range of 0,82-1,67, and the Zn content was in a range of 0,87-1,24. The result of EF was generally classified as minor enrichment. The calculation result of Igeo showed the mean of the Igeo Cu value was -0,27, and the mean of the Igeo Zn value was -0,52. The result of Igeo was generally classified as the unpolluted class of sediment.