The Andes Mountains provide an ideal natural laboratory to analyze the relationship between the tectonic evolution of a subduction margin, basin morphology, and volcanic activity. Magmatic output rates in Cordilleran-style orogenic systems vary through time and are characterized by high-flux magmatic events alternating with periods of low or no activity. The Neuquén Basin (34°S-40°S) of south-central Argentina is in a retroarc position and provides a geological record of sedimentation in variable tectonic settings. Strata ranging in age from Middle Jurassic to Neogene were sampled and analyzed to determine their detrital zircon U-Pb age spectra and Hf isotopic composition. When all detrital zircon data are combined, results indicate that significant pulses in magmatic activity occurred from 190 to 145 Ma, and at