Geographic and Gender Variability in the Prevalence of Bronchial Responsiveness in Canada

Manfreda, Jure; Sears, Malcolm R.; Becklake, Margaret R.; Chan‐Yeung, Moira; Dimich‐Ward, Helen; Siersted, Hans Christian; Ernst, Pierre; Sweet, Lamont; Til, Linda Van; Bowie, Dennis; Anthonisen, Nicholas R.

doi:10.1378/chest.125.5.1657

Cited by 60 publications

(55 citation statements)

References 31 publications

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“…In contrast to our observations in adult mice, however, healthy adult female humans are generally more sensitive to methacholine-induced airway constriction (measured as the decline in forced expiratory volume in 1 s, or FEV 1 ) than are healthy adult male humans (13,17). Whereas female mouse airways are relatively larger than those of males, the opposite is true in humans, and these anatomical differences may contribute to the apparent species difference in cholinergic airway responsiveness between sexes.…”

Section: Discussioncontrasting

confidence: 97%

Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation

Card¹,

Voltz²,

Ferguson³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussioncontrasting

confidence: 97%

Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation

Card¹,

Voltz²,

Ferguson³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…24 Geographic variability could theoretically account for regional differences in the rates of Figure 4: Adjusted ORs and 95% CIs for environmental exposures associated with an overdiagnosis of asthma among obese and nonobese adults in whom asthma had been diagnosed by a physician. Adjustments were made for high-risk occupation (firefighter, farmer, painter, mechanic or construction worker), exposure to fumes, dusts, pets and cigarette smoke.…”

Section: Discussionmentioning

confidence: 99%

“…We included people who (a) were at least 16 years old, (b) had current asthma diagnosed by a physician, and (c) were either normal body weight (body mass index [20][21][22][23][24][25] or obese (body mass index ≥ 30). We excluded overweight patients (body mass index 25-30) because we wanted a clear physiologic distinction between the 2 study groups.…”

Section: Study Populationmentioning

confidence: 99%

Overdiagnosis of asthma in obese and nonobese adults

Aaron¹,

Vandemheen²,

Boulet³

et al. 2008

Canadian Medical Association Journal

352

290

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“…However, physiological explanations are also of potential importance. Nonspecific bronchial hyperresponsiveness is found more commonly among females than males, in both general population surveys and selected smoking populations [11,12]. The association between smoking and lack of asthma control is plausibly explained by the direct airway irritant effect of tobacco smoke and the more recently described corticosteroid resistance among patients with asthma who smoke [13,14].…”

Section: Discussionmentioning

confidence: 97%

Suboptimal asthma control: prevalence, detection and consequences in general practice

Chapman¹,

Boulet²,

Rea³

et al. 2007

Eur Respir J

298

202

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Telephone surveys describing suboptimal asthma control may be biased by low response rates.In order to obtain an unbiased assessment of asthma control and assess its impact in primary care, primary care physicians used a 1-page control questionnaire in 50 consecutive asthma patients.Of the 10,428 patients assessed by 354 physicians, 59% were uncontrolled, 19% well-controlled and 23% totally controlled. Physicians overestimated control, regarding only 42% of patients as uncontrolled. Physicians were more likely to report plans to alter the regimens of uncontrolled patients than controlled patients (1.29 versus 0.20 medication changes per patient) doing so in a fashion consistent with guideline recommendations. Of the uncontrolled patients, 59% required one or more urgent care or specialist visits versus 26 and 15% of well-controlled or totally controlled patients, respectively. Patients were more likely to report short-term symptom control when they had not required urgent or specialist care (odds ratio 5.68; 95% confidence interval 4.91-6.58).The majority of asthma patients treated in general practice are uncontrolled. Lack of control can be recognised by physicians who are likely to consider appropriate changes to therapy. A lack of short-term symptom control of asthma is associated with excess healthcare utilisation.

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Geographic and Gender Variability in the Prevalence of Bronchial Responsiveness in Canada

Cited by 60 publications

References 31 publications

Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation

Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation

Overdiagnosis of asthma in obese and nonobese adults

Suboptimal asthma control: prevalence, detection and consequences in general practice

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