Geographic atrophy with choroidal thinning following brilliant blue staining

Retinal Pigment Epithelial Irregularity and Atrophy After Internal Membrane Peeling: A Report of Two Cases

“…7,19,20 Recently, however, RPE toxicity (including widespread damage and hypertrophy) and choroidal thinning have been reported after PPV with BBG-assisted ILM peeling. 21,22 In our cases, there was widespread retinal damage with RPE atrophy and clumping, which extended to the nasal retina (beyond the area of ILM peeling). In addition, of note, there was foveal sparing in both cases, which is characteristically observed in endoilluminator-induced retinal damage.…”

Macular toxicity of vital dye after pars plana vitrectomy for idiopathic epiretinal membrane: A case report

“… 1 , 2 However, recent reports have demonstrated RPE and photoreceptors damage following BBG and TB exposure for macular hole surgeries. 3 , 4 , 5 , 6 , 7 We report the first case of similar outer retinal lesions after epiretinal membrane surgery.…”

“…Although commonly used because of its high level of purity and favorable biocompatibility, 19 , 20 several cases of decreased BCVA and outer retinal damage following macular hole surgeries using TB, BBG or MBD have been published. 3 , 4 , 5 , 6 , 7 The described lesions were mottled hypo- and hyperpigmented spots on fundus examination corresponding to areas of hypo- and hyperautofluorescence, thinning of outer retinal layers and RPE, and loss of choriocapillaris on OCT. These areas of retinal damage corresponded to the areas of ILM peeling in all cases.…”