Geographic Variation in the Prevalence of Kaposi Sarcoma–Associated Herpesvirus and Risk Factors for Transmission

Sanjosé, Sílvia de; Mbisa, Georgina; Pérez-Álvarez, Susana; Benavente, Yolanda; Sukvirach, Sukhon; Hieu, Nguyen Trong; Shin, Hai‐Rim; Anh, Phạm Thị Hoàng; Thomas, J; Lazcano, Eduardo; Matos, Elena; Herrero, Rolando; Muñóz, Núbia; Molano, Mónica; Franceschi, Silvia; Whitby, Denise

doi:10.1086/598523

Cited by 85 publications

(76 citation statements)

References 31 publications

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“…study by de sanjose et al showed that HHv-8 prevalence was not statistically associated smoking status in female general population [34]. the same study also indicated that sexual transmission is not a major source of this infection.…”

Section: Discussionmentioning

confidence: 83%

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

Lai

Tsao

et al. 2014

Med Microbiol Immunol

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Human herpesvirus type 8 (HHV-8) DNA is consistently found in all types of Kaposi's sarcoma, which is prevalent in immunocompromised patients. Patients with advanced lung carcinoma often showed immunologic abnormalities, and prevalence of HHV-8 infection is unclear. In this study, blood samples from 109 lung carcinoma patients and 109 age- and sex-matched healthy controls were analyzed for lymphocyte and monocyte counts, and for antibody, DNA, and genotype of HHV-8. Lung carcinoma patients had significantly lower lymphocyte and higher monocyte counts than healthy controls (p < 0.0001, both). HHV-8 seropositivity was more prevalent in lung carcinoma patients (41.3%), particularly in male patients (50.8%), than in controls (24.8%) (p = 0.01 and 0.002, respectively). The seropositivity was also significantly higher in male (50.8%) than female patients (27.3%, p = 0.01). Titers of HHV-8 antibody in patients also significantly exceeded those in controls (p = 0.004). Under a higher threshold (antibody titer ≥1:160) which is equivalent to that of enzyme-linked immunosorbent assay, lung carcinoma patients still had higher HHV-8 seropositivity than controls (p = 0.006). Three patients with stage IV lung carcinoma were positive for HHV-8 DNA with K1 gene subtype C3, D1, and E, respectively; they had much lower lymphocyte counts (658 ± 132 µL) than patients positive for HHV-8 antibodies only (1,449 ± 873 µL). The study indicates that lung carcinoma patients, particularly males, have a high seroprevalence of HHV-8. HHV-8 DNA detected in the patients with advanced lung carcinoma may be a result of virus reactivation in the immunocompromised status.

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Section: Discussionmentioning

confidence: 83%

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

Lai

Tsao

et al. 2014

Med Microbiol Immunol

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“…We did not find anti-K8.1 antibodies in our healthy control group when using our peptide EIA. Of note, other authors have reported antibodies against recombinant K8.1 in only 2.5% of healthy Spanish control women [26].…”

Section: Discussionmentioning

confidence: 84%

Prevalence of HHV-8 in systemic autoimmune diseases

Balada¹,

Ramentol²,

Felip³

et al. 2015

Journal of Clinical Virology

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“…High prevalence of KSHV was observed in Uganda (14-86%), Congo (25-82%), Nigeria (6-56%), South Africa (16-75%), Ivory Coast (43-100%), Vietnam (11.3-15.5%), Colombia (13%), and Costa Rica (11.1%) (Sitas and Newton, 2001;Dedicoat and Newton, 2003;Sanjose, et al, 2009;Butler, et al, 2009). Therefore, it is conceivable that endemic KS may be caused by KSHV infection.…”

Section: Discussionmentioning

confidence: 99%

Increased prevalence of Kaposi΄s sarcoma-associated herpesvirus in the Kaposi΄s sarcoma-endemic area of Western Kenya in 1981–2000

Senba¹,

Buziba²,

Mori³

et al. 2011

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Geographic Variation in the Prevalence of Kaposi Sarcoma–Associated Herpesvirus and Risk Factors for Transmission

Abstract: The study provides comparable estimates of KSHV prevalence in diverse cultural settings across 4 continents and provides evidence that sexual transmission of KSHV is not a major source of infection in the general population.

Cited by 85 publications

References 31 publications

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma

Prevalence of HHV-8 in systemic autoimmune diseases

Increased prevalence of Kaposi΄s sarcoma-associated herpesvirus in the Kaposi΄s sarcoma-endemic area of Western Kenya in 1981–2000

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