Geographic variation in the use of lymphadenectomy and external‐beam radiotherapy for endometrial cancer: a cross‐sectional analysis of population‐based data

Abstract

Objective To quantify geographic variation in the use of lymphadenectomy and/or external-beam radiotherapy (EBRT) for endometrial cancer in England.Design Cross-sectional analysis of population-based data.Setting English cancer registry data, linked to chemotherapy, radiotherapy and hospital episodes statistics data.Population Twenty-two thousand four hundred and eighty-three women with endometrial cancer presenting without clinical or radiological evidence of distant metastatic spread, diagnosed in England from 2013 to 2016.Methods Proportions of patients receiving lymphadenectomy and/ or EBRT were compared across 19 Cancer Alliances, to identify variations in clinical practice. Two separate logistic regression models assessed the impact on variation of adjustment for tumour and patient characteristics.Main outcome measures Receipt of lymphadenectomy, receipt of EBRT.Results There was substantial variation by Cancer Alliance in the adjusted proportion of women with endometrial cancer receiving lymphadenectomy (range 5% [95% CI 4-6%] to 48% [95% CI 45-52%]) and EBRT (range 10% [95% CI 7-12%] to 31% [95% CI 28-33%]), after adjusting for variation in pathological grade, age, comorbidities, deprivation, ethnic group and (EBRT only) FIGO stage. Different approaches to clinical practice were identified; (i) one Cancer Alliance had significantly higher than average lymphadenectomy and significantly lower than average EBRT use, (ii) three had high use of both lymphadenectomy and EBRT, (iii) one had low lymphadenectomy use and high EBRT use, and (iv) three had low use of both lymphadenectomy and EBRT.Conclusions Lymphadenectomy is probably used to triage for EBRT when lymphadenectomy use is high and EBRT use is low. This is probably a result of variation in local endometrial cancer management guidelines, suggesting that UK recommendations should be clarified.Keywords carcinoma of the endometrium: diagnosis, carcinoma of the endometrium: radiation therapy, carcinoma of the endometrium: surgery, epidemiology: gynaecological cancer, gynaecological surgery: gynaecological cancer, gynaecology: endometrial sampling.Tweetable abstract There is geographic variation in England in the use of lymphadenectomy and radiotherapy to treat endometrial cancer.

Cohort profile: radiotherapy dataset (RTDS) in England

“…Henson et al 14 used the RTDS to investigate sociodemographic variation in the use of chemotherapy and radiotherapy in patients diagnosed with stage IV lung, oesophageal, stomach and pancreatic cancer. White et al 15 used the RTDS to quantify geographic variation in the use of lymphadenectomy and external beam radiotherapy for endometrial cancer in England. Morris et al 16 showed that wide variation exists in the use and type of radiotherapy delivered in the management of rectal cancer across the English NHS.…”