Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area

Raffi, François; Rabier, R; Foucher, Corinne; Chancerel, Bruno; Agis, F; Strobel, M

doi:10.1002/(sici)1097-0215(19990505)81:3<330::aid-ijc3>3.0.co;2-2

Cited by 14 publications

(7 citation statements)

References 16 publications

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“…HTLV seroprevalence was assessed using an enzyme-linked immunoassay (ELISA) (10,16,25,30,31,34,36,38,39,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54), enzymeimmunoassay (EIA) assay (35, 37, [55][56][57][58] or radioimmunoassay (RIA) (59)(60)(61). Confirmatory tests, when used included western blot (WB), radioimmunoprecipitation assay (RIPA) and indirect immunofluorescence assay (IFA).…”

Section: Biological Testsmentioning

confidence: 99%

Prevalence of Cancer-Associated Viral Infections in Healthy Afro-Caribbean Populations: A Review of the Literature

Ragin¹,

Edwards²,

Heron³

et al. 2008

Cancer Investigation

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Cancer is one of the five leading causes of death in the Caribbean. Viral infections have been associated with cancer development and propagation, but the prevalence of such infections in the Caribbean is unknown. This review of the published literature shows that in 161,196 subjects from 14 Caribbean Islands, the adjusted prevalence of HHV8 infection is 4.5%, HTLV-1: 1.0%, HPV: 57.5%, HCV: 0.4%, HBV: 9.4%, and EBV: 92.2%. With the exception of HCV, the prevalence was significantly higher in the Caribbean than in the United States. These findings may significantly contribute to the high incidence of cancer observed in the Caribbean.

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Section: Biological Testsmentioning

confidence: 99%

Prevalence of Cancer-Associated Viral Infections in Healthy Afro-Caribbean Populations: A Review of the Literature

Ragin¹,

Edwards²,

Heron³

et al. 2008

Cancer Investigation

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“…Familial clustering has been studied in Japan, Caribbean and Brazil [2, 9,10,11]. In these areas, vertical transmission remains the most important route of transmission, since it occurs in up to 25% of the children breastfed by seropositive mothers [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

et al. 2017

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BackgroundMolecular and epidemiological studies of transmission routes and risk factors for infection by HTLV-1 are extremely important in order to implement control measures, especially because of the high prevalence of HTLV-1 in several regions of the world. San Salvador de Jujuy, Northwest Argentina, is a highly endemic area for HTLV-1 and foci of tropical spastic paraparesis/HTLV-1-associated myelopathy.ObjectiveTo gain further insight into the role of intrafamilial transmission of HTLV-1 in a highly endemic region in Argentina.MethodCross-sectional study in Northwest Argentina. Epidemiological data and blood samples were collected from 28 HTLV-1 infected subjects (index cases) and 92 close relatives/cohabitants. HTLV-1 infection was diagnosed by detection of antibodies and proviral DNA. The LTR region was sequenced and analyzed for genetic distances (VESPA software), in addition to determination and identification of polymorphisms to define HTLV-1 family signatures.ResultsFifty seven of the 120 subjects enrolled had antibodies against HTLV-1 and were typified as HTLV-1 by PCR. The prevalence rate of HTLV-1 infection in family members of infected index cases was 31.52% (29/92). The infection was significantly associated with gender, age and prolonged lactation. Identity of LTR sequences and presence of polymorphisms revealed high prevalence of mother-to-child and interspousal transmission of HTLV-1 among these families.ConclusionThere is an ongoing and silent transmission of HTLV-1 through vertical and sexual routes within family clusters in Northwest Argentina. This evidence highlights that HTLV-1 infection should be considered as a matter of public health in Argentina, in order to introduce preventive measures as prenatal screening and breastfeeding control.

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“…L'existence de foyers localisés de forte endémie virale, par exemple les îles du sud du Japon, le Sud-Est du Gabon, certaines régions de la Colombie et de Guyane française, qui sont souvent situées près de zones d'endémie HTLV-1 plus faible, est une autre caractéristique de l'infection par ce virus. L'origine de cette répartition en foyers géo-graphiques ou ethniques, qui forment parfois de véritables puzzles dans une région donnée, est mal comprise mais pourrait être le reflet d'un effet fondateur initial dans un groupe particulier suivi de la persistance d'une forte transmission virale liée à des conditions environnementales ou socioculturelles favorables, encore mal connues [68,72]. En effet, les foyers de forte endémie HTLV-1 sont souvent constitués de groupes de populations ayant vécu de façon assez isolée durant de longues périodes.…”

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Le rétrovirus humain oncogène HTLV-1 : épidémiologie descriptive et moléculaire, origine, évolution et aspects diagnostiques et maladies associées

Gessain

2011

Bull. Soc. Pathol. Exot.

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Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) was the first oncogenic human retrovirus discovered in 1980. It is estimated that around 10-20 million people are infected with HTLV-1 worldwide. However, HTLV-1 is not a ubiquitous virus. Indeed, HTLV-1 is present throughout the world with clusters of high endemicity including mainly southern Japan, the Caribbean region, parts of South America and intertropical Africa, with foci in the Middle East and Australia. The origin of this puzzling geographical repartition is probably linked to a founder effect in certain human groups. In the high endemic areas, 0.5 to 50% of the people have antibodies against HTLV-1 antigens. HTLV-1 seroprevalence increases with age, especially in women. HTLV-1 has 3 modes of transmission: mother to child, mainly through prolonged breastfeeding (> 6 months); sexual, mainly but not exclusively occurring from male to female; and by blood products contaminated by infected lymphocytes. HTLV-1 is mainly the etiological agent of two very severe diseases: a malignant T CD4+ cell lymphoproliferation of very poor prognosis, named adult T-cell leukemia/lymphoma (ATLL), and a chronic neuro-myelopathy named tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). HTLV-1 is also associated with rare anterior uveitis, infective dermatitis and myositis in some high HTLV-1 endemic areas. The repartition of the different molecular subtypes or genotypes is mainly linked to the geographical origin of the infected persons but not to the associated pathology. HTLV-1 possesses a remarkable genetic stability probably linked to viral amplification via clonal expansion of infected cells rather than by reverse transcription. This stability can be used as a molecular tool to gain better insights into the origin, evolution and modes of dissemination of HTLV-1 and infected populations. HTLV-1 originated in humans through interspecies transmission from STLV-1, a very closely related retrovirus, highly endemic in several populations of apes and Old World monkeys.

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Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area

Cited by 14 publications

References 16 publications

Prevalence of Cancer-Associated Viral Infections in Healthy Afro-Caribbean Populations: A Review of the Literature

Prevalence of Cancer-Associated Viral Infections in Healthy Afro-Caribbean Populations: A Review of the Literature

Silent dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission

Le rétrovirus humain oncogène HTLV-1 : épidémiologie descriptive et moléculaire, origine, évolution et aspects diagnostiques et maladies associées

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