Geographical distribution of Leishmania species in Colombia, 1985-2017

Salgado-Almario, Jussep; Hernández, Carlos Arturo; Ovalle, Clemencia Elena

doi:10.7705/biomedica.v39i3.4312

Cited by 30 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…L. braziliensis is the causative agent of human CL and MCL in various countries of the American continent, including Colombia, Brazil, Nicaragua, and Ecuador, among others [ 49 , 54 , 55 ]. Thus, to validate the hybrid model constructed for Lb PTR1 and to evaluate the protein–ligand stabilities of the structures 135 , 302 , and 302a , molecular dynamics (MD) studies were performed using DHB and PMA as reference ligands.…”

Section: Resultsmentioning

confidence: 99%

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

et al. 2021

View full text Add to dashboard Cite

The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging. Natural products constitute an interesting and diverse chemical space for the identification of new antileishmanial drugs. To identify new drug options, an in-house database of 360 kauranes (tetracyclic diterpenes) was generated, and a combined ligand- and structure-based virtual screening (VS) approach was performed to select potential inhibitors of Leishmania major (Lm) pteridine reductase I (PTR1). The best-ranked kauranes were employed to verify the validity of the VS approach through LmPTR1 enzyme inhibition assay. The half-maximal inhibitory concentration (IC50) values of selected bioactive compounds were examined using the random forest (RF) model (i.e., 2β-hydroxy-menth-6-en-5β-yl ent-kaurenoate (135) and 3α-cinnamoyloxy-ent-kaur-16-en-19-oic acid (302)) were below 10 μM. A compound similar to 302, 3α-p-coumaroyloxy-ent-kaur-16-en-19-oic acid (302a), was also synthesized and showed the highest activity against LmPTR1. Finally, molecular docking calculations and molecular dynamics simulations were performed for the VS-selected, most-active kauranes within the active sites of PTR1 hybrid models, generated from three Leishmania species that are known to cause cutaneous leishmaniasis in the new world (i.e., L. braziliensis, L. panamensis, and L. amazonensis) to explore the targeting potential of these kauranes to other species-dependent variants of this enzyme.

show abstract

Section: Resultsmentioning

confidence: 99%

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

et al. 2021

View full text Add to dashboard Cite

show abstract

“…L. mexicana was reported in Antioquia in 2006 in a patient [41]. Notably, L. mexicana has been reported as causative agents of CL, but also as responsible of one case of diffuse CL [42] and other case of transfusion-transmitted VL in a immunocompromised patient [43]. L. guyanensis is reported in 12 departments in Colombia, especially those located in the Andean and Amazonian region but also in the departments of Cordoba and Sucre in the Caribbean region (Table 2).…”

Section: Discussionmentioning

confidence: 99%

An Updated Geographical Distribution of Leishmania Species Involved in Human Leishmaniasis in Colombia

Vélez

Muskus

Robledo

2021

Preprint

View full text Add to dashboard Cite

Leishmaniasis in an endemic disease in Colombia. This country ranks second in number of cases of leishmaniasis in Latin America and is one of the four countries with the largest number of Leishmania species. Although leishmaniasis is a notifiable disease, the information about the geographic distribution of Leishmania species circulating in the country is fragmented. Since 1990, when the first distribution map was published in Colombia, very few new reports have described the Leishmania species present in Colombia and their geographic distribution. In this report we included 1,833 natural isolates obtained from human cases of leishmaniasis. Their geographical origin together with those reported by other authors let us confirm the presence of Leishmania species in 30 of 32 Colombian departments, being Quindío and San Andres/Providencia free of transmission. In this work, L. braziliensis is described for first time in the departments of Atlántico, Caldas and Vaupes and L. panamensis in the departments of Guajira and Vaupés. It is also confirmed that L. panamensis and L. braziliensis coexist in the same regions being the main causative agents of cutaneous leishmaniasis in Colombia; nonetheless, L. panamensis predominates in the north and western regions whereas L. braziliensis predominates in the southeast region.

show abstract

“…Regarding Leishmania species, most of the studies were conducted on L. panamensis ( Figure 4B). This fact can be considered reasonable due to the fact that L. panamensis is the etiological agent most frequently reported in Colombia [3,6]. However, recent studies reported that L. braziliensis and L. guyanensis have relevant epidemiological reports and wide spatial distribution in Colombia [68,69].…”

Section: General Findingsmentioning

confidence: 94%

“…In Colombia, the incidence rate of this disease was 26.2 cases per 100,000 population, with 98.6% of the cases related to CL [2]. Such an incidence was due to the presence of several parasites species, including L. venezuelensis, L. equatorensis, L. lainsoni, L. colombiensis, L. mexicana, L. amazonensis, L. infantum, L. guyanensis, L. braziliensis and L. panamensis [3][4][5][6], with the last three Leishmania species being the most representative etiological agents [4,6].…”

Section: Introductionmentioning

confidence: 99%

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

2020

View full text Add to dashboard Cite

Leishmaniasis is a parasitic morbid/fatal disease caused by Leishmania protozoa. Twelve million people worldwide are appraised to be currently infected, including ca. two million infections each year, and 350 million people in 88 countries are at risk of becoming infected. In Colombia, cutaneous leishmaniasis (CL) is a public health problem in some tropical areas. Therapeutics is based on traditional antileishmanial drugs, but this practice has several drawbacks for patients. Thus, the search for new antileishmanial agents is a serious need, but the lack of adequately funded research programs on drug discovery has hampered its progress. Some Colombian researchers have conducted different research projects focused on the assessment of the antileishmanial activity of naturally occurring and synthetic compounds against promastigotes and/or amastigotes. Results of such studies have separately demonstrated important hits and reasonable potential, but a holistic view of them is lacking. Hence, we present the outcome from a systematic review of the literature (under PRISMA guidelines) on those Colombian studies investigating antileishmanials during the last thirty-two years. In order to combine the general efforts aiming at finding a lead against Leishmania panamensis (one of the most studied and incident parasites in Colombia causing CL) and to recognize structural features of representative compounds, fingerprint-based analyses using conventional machine learning algorithms and clustering methods are shown. Abstraction from such a meta-description led to describe some function-determining molecular features and simplify the clustering of plausible isofunctional hits. This systematic review indicated that the Colombian efforts for the antileishmanials discovery are increasingly intensified, though improvements in the followed pathways must be definitively pursued. In this context, a brief discussion about scope, strengths and limitations of such advances and relationships is addressed.

show abstract

Geographical distribution of Leishmania species in Colombia, 1985-2017

Cited by 30 publications

References 41 publications

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

An Updated Geographical Distribution of Leishmania Species Involved in Human Leishmaniasis in Colombia

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

Contact Info

Product

Resources

About