Geographical pattern of carcinoma gallbladder in Bihar and its association with river Ganges and arsenic levels: Retrospective individual consecutive patient data from Regional Cancer Centre

Madhawi, Richa; Pandey, Avinash; Raj, Shraddha; Mandal, Manish; Devi, Seema; Sinha, Prabhat Kumar; Singh, Radhey M.

doi:10.4103/sajc.sajc_37_18

Cited by 32 publications

(18 citation statements)

References 14 publications

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“…It has also been reported that regions with higher arsenic content (>0.05mg/dl) in the soil had 1.45 higher odds of reporting GB cancer. [17] In our study majority of cases (66.34%) were from Gangetic basin districts in comparison to the control group (40%). Gangetic belt emerged as an independent significant factor with an odd's ratio of 2.83.…”

Section: Association Between Dietary Factors and Addiction History To...mentioning

confidence: 45%

Role of demographic and dietary factors in predicting Gall Bladder Carcinoma

Ali

Maslehuddin

Jawed

et al. 2022

ijhs

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Introduction: Carcinoma of the gallbladder (GBC), is the most common cancer of the biliary tree. It is also one of the most highly malignant tumours. The aetiology of the carcinoma gall bladder is poorly understood. Chronic cholecystitis and gallstones, choledochal cysts, female gender, old age and exposure to carcinogens are some of the factors implicated in the causation of gall bladder cancer. The current changes in lifestyles of individuals about indulgence in unhealthy fat-rich food, lack of exercise, obesity, sedentary lifestyles and the high incidence of gall bladder carcinoma in Bihar, focused our attention on gall bladder carcinoma and its etiological factors. Methodology: An analytical case-control study was conducted to study the various etiological factors causing carcinoma of the gall bladder in patients of various regions of Bihar coming to PMCH Patna. A total of 101 cases of gall bladder carcinoma and a total of 101 patients without any gall bladder disease in the control group were included in the study.

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Section: Association Between Dietary Factors and Addiction History To...mentioning

confidence: 45%

Role of demographic and dietary factors in predicting Gall Bladder Carcinoma

Ali

Maslehuddin

Jawed

et al. 2022

ijhs

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“…The exact cause of which is still unknown but hypothesis including continuous arsenic exposure and proximity of river Ganga is postulated. [10] Equally alarming is the rising incidence of head-and-neck cancer in Bihar despite ban on tobacco-related products by government. [11]…”

Section: Discussionmentioning

confidence: 99%

Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis

Pandey

Raj

Madhawi

et al. 2019

South Asian J Cancer

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Background:Trends of cancer cases vary across several hospital-based cancer registries (HBCRs). There is a paucity of demographic data to evaluate trends of cancer in Eastern India.Aim:The aim of this study is to evaluate trends and pattern of cancer cases with respect to time from HBCR from Bihar.Objectives:The objective of this study is to evaluate the numbers of consecutive patients registered with eight most common type of cancer in our HBCR in Regional Cancer Centre, Bihar, and to evaluate trends of cancer cases registered with respect to time.Materials and Methods:Demographic profile of consecutive cancer patients registered from January 2014 to December 2016 (3 years) in HBCR was obtained. Patients diagnosed with common malignancies including head-and-neck cancer, gallbladder, breast, cervix, ovary, esophagus, stomach, hematolymphoid, and colorectal were analyzed. Frequency distribution, crosstabs, and line diagram were used to evaluate the trends of these common cancers with respect to time.Results:Sixty-six thousand and twenty-nine consecutive patients were registered between 2014 and 2016. Carcinoma gallbladder was the most common malignancy (21%), followed by head-and-neck cancer (19%) and breast cancer (15%). Median age at the diagnosis was 55 years for carcinoma gallbladder while 53 years and 46 years for head-and-neck and breast cancer, respectively. Male-to-female ratio was 0.6 for carcinoma gallbladder and 1.8 for head-and-neck cancer. A number of gallbladder and head-and-neck cancer registered increased by 36% (between 2014 and 2015) and 5% (between 2015 and 2016) and 24% (between 2014 and 2015) and 4% (between 2015 and 2016), respectively. Carcinoma breast and cervix showed decreasing trend with fall in registration up to 13% (between 2015 and 2016) and 27% (between 2015 and 2016), respectively.Conclusion:Carcinoma gallbladder is the most common cancer in Bihar. Head-and-neck cancer and carcinoma gallbladder are increasing while breast and cervical cancers are decreasing with respect to time.

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“…It's peculiar geographic distribution in our country with incidence rates in North India being ten times higher than South India, has been explained by the increasing industrial pollution of the Ganga and its tributaries. This has lead to exposure of the population residing in these river basins to heavy metals, pesticides, fertilizers and industrial effluents, all carcinogens implicated in causation of GBC [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Geographical Profile of Gall Bladder Cancer Patients from a Hospital-based Registry of Northern Gangetic Plains

Singh

Bhatnagar

Lohia

et al. 2022

Asian Pac J Envi & Cancer

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Purpose: Gall bladder cancer (GBC) is one of the commonest and deadliest cancers of Northern and Eastern India. The absence of a population-based cancer registry in Uttar Pradesh and Bihar has resulted in a lack of statistical information even though data from several hospital-based registries suggests that incidence rates of GBC may be one of the highest in the world. We present the four-year data on GBC from our tertiary-level multispeciality hospital. Materials & Methods: This is a retrospective and analytical study. All patients of histopathologically proven GBC over four years were included and geographic, demographic and clinical data was collected and presented. Follow up, where available, was used to assess survival at 12 months and factors affecting it. Results: A total of 245 patients with GBC were diagnosed during the study period of which more than two-thirds were women. The majority of cases at our hospital were from the state of Uttar Pradesh with the highest number coming from the Eastern districts closer to the river Ganga and its tributaries. 26.5% of cases were early stage and surgically resectable, 19.6% were locally advanced and unresectable while 53.9% were metastatic at presentation. Age, stage and radical surgery as treatment had a significant association with survival at 12 months. Conclusion: GBC has an extremely high incidence in the Northern plains of India. There is a high suspicion of its association with increasing pollution of the major rivers of the region. Early detection is crucial as definitive surgery is the only curative option with any significant improvement of survival.

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Geographical pattern of carcinoma gallbladder in Bihar and its association with river Ganges and arsenic levels: Retrospective individual consecutive patient data from Regional Cancer Centre

Cited by 32 publications

References 14 publications

Role of demographic and dietary factors in predicting Gall Bladder Carcinoma

Role of demographic and dietary factors in predicting Gall Bladder Carcinoma

Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis

Epidemiological and Geographical Profile of Gall Bladder Cancer Patients from a Hospital-based Registry of Northern Gangetic Plains

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