Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study

Increasing incidence of childhood leukaemia: a controversy re-examined

“…The subsequent decline in mortality, resulting from improvements in treatment, has been seen world-wide (Fraumeni and Miller, 1967;Coleman et al, 1993;Smith et al, 1999). Incidence has increased significantly in Europe and in the United States since the 1970s, which is essentially attributable to ALL (Coleman et al, 1993;Smith et al, 1999;Xie et al, 2003;Steliarova-Foucher et al, 2004). However, the incidence of ALL and AML has been stable in the Nordic countries between 1982 and 2001 (Hjalgrim et al, 2003).…”

“…Differences in leukaemia incidence, most apparent at ages 2 -3 years, have been observed between Caucasian and AfricanAmerican children in the United States, and between children in western and eastern Europe (Doll, 1989;Smith et al, 1999;Steliarova-Foucher et al, 2004). The development of this age peak is the main component of the overall increase in leukaemia incidence in England and Wales and other countries over the twentieth century.…”

“…In Europe, childhood lymphoid leukaemia incidence (including acute lymphoblastic leukaemia (ALL)) increased significantly by an average of 1.4% per year during 1970(Steliarova-Foucher et al, 2004. In England and Wales, the increase in ALL has been attributed to the 'common' precursor B-cell subtype (Feltbower et al, 2001;Kroll et al, 2006).…”

“…In England and Wales, the increase in ALL has been attributed to the 'common' precursor B-cell subtype (Feltbower et al, 2001;Kroll et al, 2006). Debate has arisen over whether the increase is artefactual (Leukaemia Research Fund, 2004;Adamson et al, 2005) or real (Steliarova-Foucher et al, 2004.…”

Implementation of an intensive risk‐stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in Lebanon

“…The overall incidence of ALL is 3-4 per 100,000 persons [2], with peak incidence occurring in children aged 2-5 years. In resource-rich countries, a significant increase of 1.4% per year has been described [3].…”