Geographical structure of bat SARS-related coronaviruses

Yu, Ping; Hu, Ben; Z, Shi; Cui, Jie

doi:10.1016/j.meegid.2019.02.001

Cited by 42 publications

(38 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MG772933) and only 79.5% genome sequence similarity to SARS-CoV. Phylogenetic analysis showed that the virus was clustered with SARS-CoV and bat SARSr-CoVs in subgenus Sarbecovirus Wei et al, 2020;Yu et al, 2019;Xu et al, 2020). Genomic analysis of 2019-nCoV and four typical coronaviruses (bat SARSr-CoV-Rp3, CoV-ZC45, CoV-ZXC21, and SARS-CoV-Tor2) showed a likelihood of recombination between 2019-nCoV and other coronaviruses among the subgenus .…”

mentioning

confidence: 99%

Bat origin of a new human coronavirus: there and back again

Song

Wong

et al. 2020

Sci. China Life Sci.

Self Cite

119

109

View full text Add to dashboard Cite

mentioning

confidence: 99%

Bat origin of a new human coronavirus: there and back again

Song

Wong

et al. 2020

Sci. China Life Sci.

Self Cite

119

109

View full text Add to dashboard Cite

“…We conducted a cross-sectional study in the districts of Yunnan, Guangxi, and Guangdong, China, which are known for their high levels of wildlife biodiversity, active wildlife trade activity, and historic zoonotic disease emergence events [3,5,10,14,22,24,27]. Eight study sites were selected in areas where we have previously reported diverse coronaviruses in bat populations [24] roosting close (within 5 km) to human dwellings.…”

Section: Study Location and Target Populationmentioning

confidence: 99%

Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

Mendelsohn

Zong

et al. 2019

Biosafety and Health

124

106

View full text Add to dashboard Cite

Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.

show abstract

“…In order for CoVs to recombine, they must first have the opportunity to do so by sharing overlapping geographic ranges, host species tropism, and cell and tissue tropism. Sarbecoviruses in bats tend to phylogenetically cluster according to the geographic region in which they were found [6,21]. Yu et.…”

Section: Introductionmentioning

confidence: 99%

The evolutionary history of ACE2 usage within the coronavirus subgenusSarbecovirus

Wells

Letko

Lasso

et al. 2020

Preprint

View full text Add to dashboard Cite

AbstractSARS-CoV-1 and SARS-CoV-2 are not phylogenetically closely related; however, both use the ACE2 receptor in humans for cell entry. This is not a universal sarbecovirus trait; for example, many known sarbecoviruses related to SARS-CoV-1 have two deletions in the receptor binding domain of the spike protein that render them incapable of using human ACE2. Here, we report three novel sarbecoviruses from Rwanda and Uganda which are phylogenetically intermediate to SARS-CoV-1 and SARS-CoV-2 and demonstrate via in vitro studies that they are also unable to utilize human ACE2. Furthermore, we show that the observed pattern of ACE2 usage among sarbecoviruses is most likely due to recombination. We show that the lineage that includes SARS-CoV-2 is most likely the ancestral ACE2-using lineage, and that recombination with at least one virus from this group conferred ACE2 usage to the progenitor of SARS-CoV-1 at some time in the past. We argue that alternative scenarios such as convergent evolution are much less parsimonious; we show that biogeography and patterns of host tropism support the plausibility of a recombination scenario; and we propose a competitive release hypothesis to explain how this recombination event could have occurred and why it is evolutionarily advantageous. The findings provide important insights into the natural history of ACE2 usage for both SARS-CoV-1 and SARS-CoV-2, and a greater understanding of the evolutionary mechanisms that shape zoonotic potential of coronaviruses. This study also underscores the need for increased surveillance for sarbecoviruses in southwestern China, where most ACE2-using viruses have been found to date, as well as other regions including Africa, where these viruses have only recently been discovered.

show abstract

Geographical structure of bat SARS-related coronaviruses

Cited by 42 publications

References 57 publications

Bat origin of a new human coronavirus: there and back again

Bat origin of a new human coronavirus: there and back again

Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

The evolutionary history of ACE2 usage within the coronavirus subgenusSarbecovirus

Contact Info

Product

Resources

About