Geographical variation in human papillomavirus prevalence in Mexican women with normal cytology

Orozco-Colín, Asunción; Carrillo-García, Adela; Méndez‐Tenorio, Alfonso; Ponce-de-León, Samuel; Mohar, Alejandro; Maldonado-Rodrı́guez, Rogelio; Guerra-Arias, Rocío; Flores-Gil, Octavio; Sotelo-Regil, Rita; Lizano, Marcela

doi:10.1016/j.ijid.2010.07.007

Cited by 36 publications

(44 citation statements)

References 30 publications

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“…In this study less than 50% of the women were infected with one or more HPV genotypes, which were heterogeneously distributed irrespective of their oncogenic risk. Our results are comparable with those from other studies with Mexican women [11] [18] [19]. In contrast, a meta-analysis about worldwide HPV detection among women with normal cytological findings, revealed an estimated frequency for Central America (including Mexico) of around 20%, while estimated frequencies for worldwide and developing region were 7.2% and 14.3%, respectively [20].…”

Section: Discussionsupporting

confidence: 87%

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Relevant Frequency of Multiple Infections with High- and Low-Risk HPV Genotypes among Mexican Women Attending a Tertiary Care Hospital

Flores-Medina¹,

García-Romero²,

Soriano-Becerril³

et al. 2016

OJOG

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Aims: To assess the frequency and the main HPV genotypes circulating among a group of women attending at a third level Hospital in Mexico City. Methods: A cross-sectional and descriptive study was performed in a group of 143 female outpatients of the Gynecology and Obstetrics Service at the National Institute of Perinatology of Mexico. Cervical swabs were taken from participants and subjected to simultaneous detection/genotyping of HPV by Linear Array Genotyping Test (Roche Molecular Systems). Mann-Whitney U, median and/or Square Chi tests were used to compare socio-demographical features between HPV-infected and uninfected women. Results: A total of 66 women (46.2%) had HPV infection. Overall, 112 genotypes were detected either as single infections (45.5%) or multiple genotype infections (54.5%). The cumulated frequency of multiple infections with high-/low-and high-/high-risk HPV genotypes was 63.9 %. The most frequent high-risk genotypes were HPV52 HPV58 and HPV51, whereas the most frequent low-risk genotypes were HPV6, HPV53 and HPV84. Infected women were significantly younger and have less stable partner relationships than uninfected women (p < 0.05). Conclusion: A relevant frequency of mixed infections with high-and low-risk HPV genotypes, other than those consi-* Corresponding author. S. Flores-Medina et al.425 dered most prevalent worldwide, was observed. Most circulating high-risk genotypes among the women of this study are not covered by commercial vaccine formulations.

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Section: Discussionsupporting

confidence: 87%

“…Rise in worldwide HPV prevalence among women, and consequently a rise in cases of cervical cancer (from 378,000 cases per year in 1980 to 454,000 cases per year in 2010), has been observed in the past 2 decades, although it varies geographically, and according to age and other factors [11]- [15].…”

Section: Discussionmentioning

confidence: 99%

Relevant Frequency of Multiple Infections with High- and Low-Risk HPV Genotypes among Mexican Women Attending a Tertiary Care Hospital

Flores-Medina¹,

García-Romero²,

Soriano-Becerril³

et al. 2016

OJOG

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“…Some studies concerning HPV in Mexico have shown some differences in the prevalence reported. Such differences range from 4.8% to 40.9% and suggest a variability of HPV frequencies regarding geographical zone (Torroella-Kouri et al, 1998;Gonzalez-Losa et al, 2004;Pina-Sanchez et al, 2006;Sanchez-Anguiano et al, 2006;Lopez-Revilla et al, 2008;Velazquez-Marquez et al, 2009;Canul-Canche et al, 2010;Illades-Aguilar et al, 2010;Orozco-Colin et al, 2010;Velazquez-Marquez et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security

Salcedo¹,

Piña‐Sánchez²,

Vallejo-Ruíz³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at the Mexican Institute for Social Security from different areas of Mexico. Materials and Methods: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC. Results: Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association. Conclusions: The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.

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“…5 HPV is classified as low or high risk based on its association with premalignant and malignant lesions, respectively. Low-risk HPVs include 6,11,40,42,43,44,54,61,70,72, and 81. Of these types, 6 and 11 cause 90% of cases of anogenital warts and low grade in cervical cells.…”

Section: Introductionmentioning

confidence: 99%

“…10 In Mexico, HPV 16, 18, 31, 33, 39, 45, 53, 58 and 59 have frequently been found in normal cervical samples. [11][12][13][14][15][16][17] In the year 2015 in the United States they report that the most common highrisk human papillomavirus is serotype 16, associated with precancerous lesions in the cervix and conferring greater risk of disease of high-grade lesions; also reported that 50% of adenocarcinoma in situ and 50% of cases of invasive cancer were attributable to HPV infection 18.…”

Section: Introductionmentioning

confidence: 99%

Correlation of the HPV genotype with the degree of dysplasia in patients with cervicouter cancer in the General Hospital Naval of high specialty

Morales¹,

Araiza²,

Garay³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONCervical cancer is the second most common cancer among women worldwide.1 It is the second leading cause of mortality due to malignant neoplasia in women, producing up to 11 deaths per day affecting the age group of 25-69 years and only is outweighed by breast cancer. 2In Mexico, human papillomavirus infection is the cause of a large percentage of cervical cancer; is one of the main public health problems, with an incidence of 15.5% and a mortality of 12.8%.3 It has been identified that there are differences in the prevalence of type of HPV. 4 ABSTRACTBackground: Cervical-uterine cancer (CaCu) is the second leading cause of death in women worldwide and the first in developing countries. It has been correlated to human papillomavirus (HPV) genotype with cancerous lesions reported in histopathological studies, which tells us about the prognosis of the patients. Objective of present study was to correlate the genotype of HPV to the histopathological result evaluated in these patients at the Naval Hospital of High Specialty. Methods: A total of 316 women attended at the Naval General High Marine Hospital from 2015 to 2016 with HPV diagnosis were included, the histopathological report was correlated with the HPV genotype determined by the chain reaction of the polymerase (PCR). Statistical tests were applied for Smirnov and Kolmogorov, Chi square, OR, Anova-Kruskal Wallis. Data were processed using the SPSS software version 19 and a P <0.05 was taken as statistical significance. Results: The mean age was 36.0±10.2. The detection of cervical cancer was reported in 3.8% and stage CIN III 2.5%; the highest proportion of patients were in the CIN I stage (51.3%), while the CIN II was 9.2%, and up to 30.7% were classified as HPV infection; only 2.5% were normal. The types of HPV prevalent by PCR were those at high risk different from 16 and 18 with a rate of 34.8%, then 16 at 5.1% and 18 at 0.3%. More than half of the cases (54.4%) were negative for the serotypes analyzed. In general terms, CaCu and CIN III were observed in 15% of the type 16, 0% in type 18, 25% in other high risk and 60% in negative PCR. Conclusions: In this study, we obtained essential data that tells us that this population could be treated with low-risk HPV types associated with CaCu.

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Geographical variation in human papillomavirus prevalence in Mexican women with normal cytology

Abstract: Regional differences in HPV prevalence and distribution show an apparent geographic boundary between the studied populations that deserves further analysis, taking into account other factors such as those related to the sexual partners.

Cited by 36 publications

References 30 publications

Relevant Frequency of Multiple Infections with High- and Low-Risk HPV Genotypes among Mexican Women Attending a Tertiary Care Hospital

Relevant Frequency of Multiple Infections with High- and Low-Risk HPV Genotypes among Mexican Women Attending a Tertiary Care Hospital

Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security

Correlation of the HPV genotype with the degree of dysplasia in patients with cervicouter cancer in the General Hospital Naval of high specialty

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