1984
DOI: 10.1038/bjc.1984.238
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Geographical variations in the incidence of colorectal cancer in Britain

Abstract: Summary The incidence of colorectal cancer was compared in nine towns in England and Wales, chosen to encompass a range of socio-economic conditions and spread of latitude in the country. Cases were ascertained through pathology records, supplemented by clinical notes. The pattern of variation in incidence was different for men and women. Among men incidences were highest in towns with better socio-economic conditions, whereas among women the trend was reversed. This supports the hypothesis that the dominant a… Show more

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Cited by 10 publications
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“…He was a canny sleuth and sought clues to aetiology and evidence of modifiable environmental influences as steps towards preventive medicine. For over two decades he investigated patterns of diseases ranging from diabetes and thyrotoxicosis (Barker & Phillips, 1984) to Paget's (Barker & Gardner, 1974) and Perthes' disease ; gall stones (Brett & Barker, 1976), urinary stones (Barker & Donnan, 1978), gout and Henoch-Schonlein purpura (Atkinson & Barker, 1976); duodenal ulcers (Barker et al, 1981), colorectal cancer (Barker & Godfrey, 1984) and respiratory infections (Barker & Osmond, 1986b); polio (Martyn et al, 1988) and Alzheimer's disease (Martyn et al, 1989). This prodigious work included one of his less well known scientific contributions -the initiation of what is now referred to as the ''hygiene hypothesis''.…”
Section: Obituary For Professor David Barkermentioning
confidence: 99%
“…He was a canny sleuth and sought clues to aetiology and evidence of modifiable environmental influences as steps towards preventive medicine. For over two decades he investigated patterns of diseases ranging from diabetes and thyrotoxicosis (Barker & Phillips, 1984) to Paget's (Barker & Gardner, 1974) and Perthes' disease ; gall stones (Brett & Barker, 1976), urinary stones (Barker & Donnan, 1978), gout and Henoch-Schonlein purpura (Atkinson & Barker, 1976); duodenal ulcers (Barker et al, 1981), colorectal cancer (Barker & Godfrey, 1984) and respiratory infections (Barker & Osmond, 1986b); polio (Martyn et al, 1988) and Alzheimer's disease (Martyn et al, 1989). This prodigious work included one of his less well known scientific contributions -the initiation of what is now referred to as the ''hygiene hypothesis''.…”
Section: Obituary For Professor David Barkermentioning
confidence: 99%