International audiencePaleohydrological and archaeological evidence from the Southern and South-Eastern Arabian Peninsula reveal strong relations between phases of human settlements and climate change linked to the Indian monsoon system. During the early to mid-Holocene, large fresh-water lakes extended in the lowland deserts of Ramlat as-Sab'atayn (Yemen) and Wahiba Sands (Oman), which were very similar to those occurring in the North, in the Rub' al-Khali (Saudi Arabia), at that time. Many archaeological sites, characterized by scattered stone artefacts, ostrich-eggshells and bones around hearths, are related to this lacustrine phase, which culminated around 10 0008000 cal yr B.P. in the lowland deserts before the lakes progressively dried up. The last record of fresh-water bodies' extensions date back 7300 cal yr B.P. at Shabwa (Yemen) and 7500 cal yr B.P. at al-Haid (Oman). Then, fresh-water was probably available only from seasonal run-off from adjacent highlands, where paleolakes persisted into the late Holocene. Dry climate conditions in the inland desert of Yemen during the late Holocene coincide with a phase of intensive human inhabitation as testified by development of irrigation in the piedmontane areas, numerous necropolises of built collective burials and houses