Ba-rich minerals are frequently observed in epithermal environments and include characteristic phases such as barite and alunite supergroup minerals. At Yellowstone, in-situ EPMA-WDS show that Ba in the unaltered third-cycle Tuff of Sulphur Creek is largely contained within sanidine phenocrysts (mean 1.60 wt% BaO) with lesser concentrations in plagioclase (mean 0.22 wt% BaO) and volcanic glass (mean 0.05 wt% BaO). Whole-rock XRD analyses of rocks hydrothermally altered by alkaline-chloride fluids at Ridge 7741 in Seven Mile Hole, Yellowstone National Park, show they are dominated by illite + quartz ± hydrothermal feldspar, primarily adularia. In this alteration zone, adularia is the principal phase that contains significant Ba (mean 0.43 wt% BaO). In shallower alteration, dominated by acid-sulfate assemblages, such as kaolinite + opaline silica ± alunite supergroup minerals (alunite, walthierite, huangite) ± barite, Ba is sequestered in the sulfate minerals. Alunite supergroup minerals (mean 1.12 wt% BaO) are more prevalent than barite and are largely found from the modern valley rim to about 60m below the modern surface, especially around the South Fork of Sulphur Creek. However, nearly 80 m below the modern rim of the Grand Canyon of the Yellowstone River, in areas previously altered by alkaline-chloride fluids, adularia altered to alunite supergroup minerals may contain similar to slightly elevated Ba concentrations relative to the replaced grain. Barite is primarily found sporadically in altered rocks along the valley rim of the South Fork of Sulphur This is the peer-reviewed, final accepted version for American Mineralogist, published by the Mineralogical Society of America.The published version is subject to change. Cite as Authors (Year) Title. American Mineralogist, in press.