Geologische Forschung im Apennin

Bubnoff, S. v.

doi:10.1007/bf01473966

Naturwissenschaften

1936

DOI: 10.1007/bf01473966

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Geologische Forschung im Apennin

S. v. Bubnoff

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2007

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“…The only previous report that we found of anticonvulsant activity of p-hydroxybenzoic acid esters is its ability to control cocaine-induced cramps, through i.v. and intra-arterial administration, which the authors of the report have related to vasodilator effects [40]. Bibliographic search through SciFinder has not pointed out other reports of anticonvulsant activity of MPB and PPB [41].…”

mentioning

confidence: 99%

A successful virtual screening application: prediction of anticonvulsant activity in MES test of widely used pharmaceutical and food preservatives methylparaben and propylparaben

Talevi

Bellera

Castro

et al. 2007

J Comput Aided Mol Des

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A discriminant function based on topological descriptors was derived from a training set composed by anticonvulsants of clinical use or in clinical phase of development and compounds with other therapeutic uses. This model was internally and externally validated and applied in the virtual screening of chemical compounds from the Merck Index 13th. Methylparaben (Nipagin), a preservative widely used in food, cosmetics and pharmaceutics, was signaled as active by the discriminant function and tested in mice in the Maximal Electroshock (MES) test (i.p. administration), according to the NIH Program for Anticonvulsant Drug Development. Based on the results of Methylparaben, Propylparaben (Nipasol), another preservative usually used in association with the former, was also tested. Both methyl and propylparaben were found active in mice at doses of 30, 100, and 300 mg/kg. The discovery of the anticonvulsant activities in the MES test of methylparaben and propylparaben might be useful for the development of new anticonvulsant medications, specially considering the well-known toxicological profile of these drugs.

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mentioning

confidence: 99%

A successful virtual screening application: prediction of anticonvulsant activity in MES test of widely used pharmaceutical and food preservatives methylparaben and propylparaben

Talevi

Bellera

Castro

et al. 2007

J Comput Aided Mol Des

View full text Add to dashboard Cite

show abstract

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Geologische Forschung im Apennin

Cited by 1 publication

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A successful virtual screening application: prediction of anticonvulsant activity in MES test of widely used pharmaceutical and food preservatives methylparaben and propylparaben

A successful virtual screening application: prediction of anticonvulsant activity in MES test of widely used pharmaceutical and food preservatives methylparaben and propylparaben

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