In the South Okhotsk Sea province – on the islands of Sakhalin, Kunashir, Iturup, Urup and surrounding sea areas – many occurrences of rare, noble metal and other mineralizations as well as of oil-and-gas fields, gas hydrate accumulations, and isolated areas of active emission of water-hydrocarbon gases are known. Occurrences and deposits of solid, liquid and gaseous mineral resources are controlled by hidden deep fault transform zones: Nosappu (Tuscarora), Iturup, and Urup. These long-lived extended (more than 1000 km) zones are distinguished at the N-W Pacific megaplate margin near the S-E flank of the Kuril-Kamchatka trogue. Using the seismotomographic methods we have established their extension to the west from the seismic focal zone in the oceanic slab that subducted into the transition zone of the mantle. In the areas of strike-slip extension the faults accounted for the active formation of the drainage channels for the penetration of the sea water in the lithosphere with the following serpentinization of its ultramafites, and for decompressional generation of ascending mantle-derived abiogenic fluid flows. The latter penetrated from the underslab asthenosphere in the oversubduction mantle wedge and beneath the lithospheric mantle, where they accounted for the development of the processes of metasomatism. The subsequent migration of flows initiated the creation of primary magma reservoirs in the lower parts of the continental lithosphere, and intermediate and peripheral chambers in the Earth’s crust. The injection of melts from the chambers in the consolidated Earth's crust led to the formation of abyssal, hypabyssal intrusive massifs, arch-dome uplifts and magmatogenic-ore (ore-magmatic) systems predominantly among the rocks of the pre-Pliocene basement. The concentration of oil and gas accumulations mainly from the mantle-derived abiogenic hydrocarbons containing mercury, gold, rhenium, and PGE in the Cenozoic sedimentary basins amidst the reservoirs under the impermeable beds also resulted from deep under- and overslab fluid flows.