One of the most important information related to molecular graphs is given by the determination (when possible) of upper and lower bounds for their corresponding topological indices. Such bounds allow to establish the approximate range of the topological indices in terms of molecular structural parameters. The purpose of this paper is to provide new inequalities relating several classes of variable topological indices including the first and second general Zagreb indices, the general sum-connectivity index, and the variable inverse sum deg index. Also, upper and lower bounds on the inverse degree in terms of the first general Zagreb are found. Moreover, the characterization of extremal graphs with respect to many of these inequalities is obtained. Finally, some applications are given.