2007
DOI: 10.1159/000109078
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Geometric Characteristics of Arterial Network of Rat Pial Microcirculation

Abstract: Objective: The aim of the study was to assess the geometric characteristics of rat pial microcirculation and describe the vessel bifurcation patterns by ‘connectivity matrix’. Methods: Male Wistar rats were used to visualize pial microcirculation by a fluorescent microscopy technique through an open cranial window, using fluorescein isothiocyanate bound to dextran (molecular weight 70 kDa). The arteriolar network was mapped by stop-frame images. Diameters and lengths of arterioles were measured with a computer… Show more

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Cited by 50 publications
(71 citation statements)
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“…We classified the arterioles, starting from the smallest ones assigned order 1 that gave origin to capillaries (order 0) up to the largest arterioles in the preparation, assigned order 5. The geometric characteristics of the 5 arteriolar orders indicate that diameter, length and bifurcation grew as a geometric sequence with the order number in accordance with Horton’s law, as reported [32]. A system obeying such a law is fractal.…”
Section: Discussionsupporting
confidence: 78%
“…We classified the arterioles, starting from the smallest ones assigned order 1 that gave origin to capillaries (order 0) up to the largest arterioles in the preparation, assigned order 5. The geometric characteristics of the 5 arteriolar orders indicate that diameter, length and bifurcation grew as a geometric sequence with the order number in accordance with Horton’s law, as reported [32]. A system obeying such a law is fractal.…”
Section: Discussionsupporting
confidence: 78%
“…2B and 3 A and B). Lastly, we note that although some past studies describe the pial network of the MCA solely in terms of trees (36,37), these studies analyzed only relatively small portions of the total network and, furthermore, had low spatial resolution. The present work avoids these limitations and further shows that mice and rats share the same topology (Figs.…”
Section: Discussionmentioning
confidence: 99%
“…If two daughter vessels were of different orders, the parent vessel retained the higher of the two. The procedure of the pial arteriole classification has been reported previously [32]. A ‘connectivity matrix' was also calculated to clarify the number and order of daughter arterioles spreading from parent vessels.…”
Section: Methodsmentioning
confidence: 99%
“…A ‘connectivity matrix' was also calculated to clarify the number and order of daughter arterioles spreading from parent vessels. Briefly, order n vessels may spring from orders n + 1, n + 2, … vessels, the component of which in row n and column m was the ratio of the total number of elements of order n sprung from elements in order m [32] (see Appendix for more details). …”
Section: Methodsmentioning
confidence: 99%
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