Genuine multipartite entanglement is crucial for quantum information and related technologies, but quantifying it has been a long-standing challenge. Most proposed measures do not meet the “genuine” requirement, making them unsuitable for many applications. In this work, we propose a journey toward addressing this issue by introducing an unexpected relation between multipartite entanglement and hypervolume of geometric simplices, leading to a tetrahedron measure of quadripartite entanglement. By comparing the entanglement ranking of two highly entangled four-qubit states, we show that the tetrahedron measure relies on the degree of permutation invariance among parties within the quantum system. We demonstrate potential future applications of our measure in the context of quantum information scrambling within many-body systems.